Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells

The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA),...

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Autores principales: Chao, Hsiao-Mei, Wang, Teh-Wei, Chern, Edward, Hsu, Shan-hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048531/
https://www.ncbi.nlm.nih.gov/pubmed/35582099
http://dx.doi.org/10.4251/wjgo.v14.i4.748
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author Chao, Hsiao-Mei
Wang, Teh-Wei
Chern, Edward
Hsu, Shan-hui
author_facet Chao, Hsiao-Mei
Wang, Teh-Wei
Chern, Edward
Hsu, Shan-hui
author_sort Chao, Hsiao-Mei
collection PubMed
description The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment.
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spelling pubmed-90485312022-05-16 Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells Chao, Hsiao-Mei Wang, Teh-Wei Chern, Edward Hsu, Shan-hui World J Gastrointest Oncol Review The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and metastasis, have been indicated to be responsible for the poor prognosis of patients with colon cancers. The epigenetic regulatory network plays a crucial role in CSC properties. Regulatory non-coding RNA (ncRNA), including microRNAs, long noncoding RNAs, and circular RNAs, have an important influence on cell physiopathology. They modulate cells by regulating gene expression in different ways. This review discusses the basic characteristics and the physiological functions of colorectal cancer (CRC) stem cells. Elucidation of these ncRNAs will help us understand the pathological mechanism of CRC progression, and they could become a new target for cancer treatment. Baishideng Publishing Group Inc 2022-04-15 2022-04-15 /pmc/articles/PMC9048531/ /pubmed/35582099 http://dx.doi.org/10.4251/wjgo.v14.i4.748 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Chao, Hsiao-Mei
Wang, Teh-Wei
Chern, Edward
Hsu, Shan-hui
Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title_full Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title_fullStr Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title_full_unstemmed Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title_short Regulatory RNAs, microRNA, long-non coding RNA and circular RNA roles in colorectal cancer stem cells
title_sort regulatory rnas, microrna, long-non coding rna and circular rna roles in colorectal cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048531/
https://www.ncbi.nlm.nih.gov/pubmed/35582099
http://dx.doi.org/10.4251/wjgo.v14.i4.748
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