Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source

A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C–N bond and multi C–S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to...

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Detalles Bibliográficos
Autores principales: Ni, Penghui, Tan, Jing, Li, Rong, Huang, Huawen, Zhang, Feng, Deng, Guo-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048575/
https://www.ncbi.nlm.nih.gov/pubmed/35492663
http://dx.doi.org/10.1039/c9ra09656f
Descripción
Sumario:A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C–N bond and multi C–S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to the high efficiency of this transformation under metal-free conditions.

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