Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source

A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C–N bond and multi C–S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to...

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Detalles Bibliográficos
Autores principales: Ni, Penghui, Tan, Jing, Li, Rong, Huang, Huawen, Zhang, Feng, Deng, Guo-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048575/
https://www.ncbi.nlm.nih.gov/pubmed/35492663
http://dx.doi.org/10.1039/c9ra09656f
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author Ni, Penghui
Tan, Jing
Li, Rong
Huang, Huawen
Zhang, Feng
Deng, Guo-Jun
author_facet Ni, Penghui
Tan, Jing
Li, Rong
Huang, Huawen
Zhang, Feng
Deng, Guo-Jun
author_sort Ni, Penghui
collection PubMed
description A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C–N bond and multi C–S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to the high efficiency of this transformation under metal-free conditions.
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spelling pubmed-90485752022-04-28 Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source Ni, Penghui Tan, Jing Li, Rong Huang, Huawen Zhang, Feng Deng, Guo-Jun RSC Adv Chemistry A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C–N bond and multi C–S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to the high efficiency of this transformation under metal-free conditions. The Royal Society of Chemistry 2020-01-23 /pmc/articles/PMC9048575/ /pubmed/35492663 http://dx.doi.org/10.1039/c9ra09656f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ni, Penghui
Tan, Jing
Li, Rong
Huang, Huawen
Zhang, Feng
Deng, Guo-Jun
Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title_full Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title_fullStr Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title_full_unstemmed Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title_short Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
title_sort brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048575/
https://www.ncbi.nlm.nih.gov/pubmed/35492663
http://dx.doi.org/10.1039/c9ra09656f
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