Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions

CRISPR-Cas systems acquire heritable defense memory against invading nucleic acids through adaptation. Type III CRISPR-Cas systems have unique and intriguing features of defense and are important in method development for Genetics research. We started to understand the common and unique properties o...

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Detalles Bibliográficos
Autores principales: Zhang, Xinfu, An, Xinmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048733/
https://www.ncbi.nlm.nih.gov/pubmed/35495695
http://dx.doi.org/10.3389/fmicb.2022.876174
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author Zhang, Xinfu
An, Xinmin
author_facet Zhang, Xinfu
An, Xinmin
author_sort Zhang, Xinfu
collection PubMed
description CRISPR-Cas systems acquire heritable defense memory against invading nucleic acids through adaptation. Type III CRISPR-Cas systems have unique and intriguing features of defense and are important in method development for Genetics research. We started to understand the common and unique properties of type III CRISPR-Cas adaptation in recent years. This review summarizes our knowledge regarding CRISPR-Cas adaptation with the emphasis on type III systems and discusses open questions for type III adaptation studies.
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spelling pubmed-90487332022-04-29 Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions Zhang, Xinfu An, Xinmin Front Microbiol Microbiology CRISPR-Cas systems acquire heritable defense memory against invading nucleic acids through adaptation. Type III CRISPR-Cas systems have unique and intriguing features of defense and are important in method development for Genetics research. We started to understand the common and unique properties of type III CRISPR-Cas adaptation in recent years. This review summarizes our knowledge regarding CRISPR-Cas adaptation with the emphasis on type III systems and discusses open questions for type III adaptation studies. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9048733/ /pubmed/35495695 http://dx.doi.org/10.3389/fmicb.2022.876174 Text en Copyright © 2022 Zhang and An. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhang, Xinfu
An, Xinmin
Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title_full Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title_fullStr Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title_full_unstemmed Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title_short Adaptation by Type III CRISPR-Cas Systems: Breakthrough Findings and Open Questions
title_sort adaptation by type iii crispr-cas systems: breakthrough findings and open questions
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048733/
https://www.ncbi.nlm.nih.gov/pubmed/35495695
http://dx.doi.org/10.3389/fmicb.2022.876174
work_keys_str_mv AT zhangxinfu adaptationbytypeiiicrisprcassystemsbreakthroughfindingsandopenquestions
AT anxinmin adaptationbytypeiiicrisprcassystemsbreakthroughfindingsandopenquestions

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