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Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression

Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function...

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Autores principales: Shan, Dan-Dan, Zheng, Qiu-Xian, Wang, Jing, Chen, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048787/
https://www.ncbi.nlm.nih.gov/pubmed/35581965
http://dx.doi.org/10.3748/wjg.v28.i16.1641
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author Shan, Dan-Dan
Zheng, Qiu-Xian
Wang, Jing
Chen, Zhi
author_facet Shan, Dan-Dan
Zheng, Qiu-Xian
Wang, Jing
Chen, Zhi
author_sort Shan, Dan-Dan
collection PubMed
description Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function extensively in numerous physiological and pathological processes. Small nucleolar RNA host gene 3 (SNHG3) is a novel lncRNA and has been reported to be differentially expressed in various tumors, such as liver cancer, gastric cancer, and glioma. However, the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly understood. In this review, we summarize the results of SNHG3 studies in humans, animal models, and cells to underline the expression and role of SNHG3 in cancer. SNHG3 expression is upregulated in most tumors and is detrimental to patient prognosis. SNHG3 expression in lung adenocarcinoma remains controversial. Concurrently, SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms, including competing endogenous RNA effects. A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment.
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spelling pubmed-90487872022-05-16 Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression Shan, Dan-Dan Zheng, Qiu-Xian Wang, Jing Chen, Zhi World J Gastroenterol Review Cancer has become the most life-threatening disease in the world. Mutations in and aberrant expression of genes encoding proteins and mutations in noncoding RNAs, especially long noncoding RNAs (lncRNAs), have significant effects in human cancers. LncRNAs have no protein-coding ability but function extensively in numerous physiological and pathological processes. Small nucleolar RNA host gene 3 (SNHG3) is a novel lncRNA and has been reported to be differentially expressed in various tumors, such as liver cancer, gastric cancer, and glioma. However, the interaction mechanisms for the regulation between SNHG3 and tumor progression are poorly understood. In this review, we summarize the results of SNHG3 studies in humans, animal models, and cells to underline the expression and role of SNHG3 in cancer. SNHG3 expression is upregulated in most tumors and is detrimental to patient prognosis. SNHG3 expression in lung adenocarcinoma remains controversial. Concurrently, SNHG3 affects oncogenes and tumor suppressor genes through various mechanisms, including competing endogenous RNA effects. A deeper understanding of the contribution of SNHG3 in clinical applications and tumor development may provide a new target for cancer diagnosis and treatment. Baishideng Publishing Group Inc 2022-04-28 2022-04-28 /pmc/articles/PMC9048787/ /pubmed/35581965 http://dx.doi.org/10.3748/wjg.v28.i16.1641 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Review
Shan, Dan-Dan
Zheng, Qiu-Xian
Wang, Jing
Chen, Zhi
Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title_full Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title_fullStr Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title_full_unstemmed Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title_short Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
title_sort small nucleolar rna host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048787/
https://www.ncbi.nlm.nih.gov/pubmed/35581965
http://dx.doi.org/10.3748/wjg.v28.i16.1641
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