Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Harmane, a compound derived from Peganum harmala L., was discovered as a lipid accumulation inhibitor with our triglyceride (TG) assay. To investigate the molecular mechanism underlying the role of harmane in the prevention of lipid accumulation, a number of biological experiments have been designed...

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Autores principales: Li, Yanwen, Li, Chanjuan, Wu, Jiaqiang, Liu, Wenfeng, Li, Dongli, Xu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049078/
https://www.ncbi.nlm.nih.gov/pubmed/35495252
http://dx.doi.org/10.1039/c9ra09383d
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author Li, Yanwen
Li, Chanjuan
Wu, Jiaqiang
Liu, Wenfeng
Li, Dongli
Xu, Jun
author_facet Li, Yanwen
Li, Chanjuan
Wu, Jiaqiang
Liu, Wenfeng
Li, Dongli
Xu, Jun
author_sort Li, Yanwen
collection PubMed
description Harmane, a compound derived from Peganum harmala L., was discovered as a lipid accumulation inhibitor with our triglyceride (TG) assay. To investigate the molecular mechanism underlying the role of harmane in the prevention of lipid accumulation, a number of biological experiments have been designed to determine if harmane reduces lipid accumulation by suppressing adipogenesis, lipogenesis, and regulating a specific signal transduction pathway. Our experimental data show that harmane inhibits TG accumulation though down-regulating the expression of adipogenic and lipogenic factors, up-regulating adipocyte browning markers and activating the SIRT1-LKB1-AMPK pathway. Therefore, harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning.
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spelling pubmed-90490782022-04-28 Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning Li, Yanwen Li, Chanjuan Wu, Jiaqiang Liu, Wenfeng Li, Dongli Xu, Jun RSC Adv Chemistry Harmane, a compound derived from Peganum harmala L., was discovered as a lipid accumulation inhibitor with our triglyceride (TG) assay. To investigate the molecular mechanism underlying the role of harmane in the prevention of lipid accumulation, a number of biological experiments have been designed to determine if harmane reduces lipid accumulation by suppressing adipogenesis, lipogenesis, and regulating a specific signal transduction pathway. Our experimental data show that harmane inhibits TG accumulation though down-regulating the expression of adipogenic and lipogenic factors, up-regulating adipocyte browning markers and activating the SIRT1-LKB1-AMPK pathway. Therefore, harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning. The Royal Society of Chemistry 2020-01-27 /pmc/articles/PMC9049078/ /pubmed/35495252 http://dx.doi.org/10.1039/c9ra09383d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Yanwen
Li, Chanjuan
Wu, Jiaqiang
Liu, Wenfeng
Li, Dongli
Xu, Jun
Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title_full Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title_fullStr Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title_full_unstemmed Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title_short Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
title_sort harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049078/
https://www.ncbi.nlm.nih.gov/pubmed/35495252
http://dx.doi.org/10.1039/c9ra09383d
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