Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5

This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broad-spectrum activity against several pathogens....

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Detalles Bibliográficos
Autores principales: Thandayuthapani, Deepika, Chinnappa, Nivetha, Annavi, Arjunan, Manickam, Muthusevam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049086/
https://www.ncbi.nlm.nih.gov/pubmed/35539891
http://dx.doi.org/10.6026/97320630017809
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author Thandayuthapani, Deepika
Chinnappa, Nivetha
Annavi, Arjunan
Manickam, Muthusevam
author_facet Thandayuthapani, Deepika
Chinnappa, Nivetha
Annavi, Arjunan
Manickam, Muthusevam
author_sort Thandayuthapani, Deepika
collection PubMed
description This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broad-spectrum activity against several pathogens. So the isolate was used for overall metabolic profiling studies on crude extract and phylogeny pattern analysis of NRPS A-domain, which is an important gene clusters and plays vital role in production of bioactive metabolites. The result suggests that Actinobacterium dagang 5 has the potential to produce a new type of antibacterial compounds.
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spelling pubmed-90490862022-05-09 Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5 Thandayuthapani, Deepika Chinnappa, Nivetha Annavi, Arjunan Manickam, Muthusevam Bioinformation Research Article This study aims to find out the mapping of bioactive compounds by combinational analysis of regulatory machinery pattern study and metabolomics approach. In which we isolated a highly potent Actinobacterium dagang 5 from Gulf of Manner, which shows broad-spectrum activity against several pathogens. So the isolate was used for overall metabolic profiling studies on crude extract and phylogeny pattern analysis of NRPS A-domain, which is an important gene clusters and plays vital role in production of bioactive metabolites. The result suggests that Actinobacterium dagang 5 has the potential to produce a new type of antibacterial compounds. Biomedical Informatics 2021-09-30 /pmc/articles/PMC9049086/ /pubmed/35539891 http://dx.doi.org/10.6026/97320630017809 Text en © 2021 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Thandayuthapani, Deepika
Chinnappa, Nivetha
Annavi, Arjunan
Manickam, Muthusevam
Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title_full Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title_fullStr Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title_full_unstemmed Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title_short Phylogenetic and sequence profile analysis of Non-Ribosomal Polyketide Synthase-Adenylation (NRPS)domain from Actinobacterium dagang 5
title_sort phylogenetic and sequence profile analysis of non-ribosomal polyketide synthase-adenylation (nrps)domain from actinobacterium dagang 5
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049086/
https://www.ncbi.nlm.nih.gov/pubmed/35539891
http://dx.doi.org/10.6026/97320630017809
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