Cargando…
Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus
Spexin is novel biomarker, which plays a potential role in glucose and lipid metabolisms. However, there was paucity of serum spexin levels in obesity and diabetes mellitus subjects. Hence the current study was aimed to find the relationship between the serum spexin levels in type 2 Diabetes mellitu...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Biomedical Informatics
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049087/ https://www.ncbi.nlm.nih.gov/pubmed/35539887 http://dx.doi.org/10.6026/97320630017790 |
_version_ | 1784696067690856448 |
---|---|
author | Tejaswi, G Dayanand, CD Prabhakar, K |
author_facet | Tejaswi, G Dayanand, CD Prabhakar, K |
author_sort | Tejaswi, G |
collection | PubMed |
description | Spexin is novel biomarker, which plays a potential role in glucose and lipid metabolisms. However, there was paucity of serum spexin levels in obesity and diabetes mellitus subjects. Hence the current study was aimed to find the relationship between the serum spexin levels in type 2 Diabetes mellitus (type 2 DM) with extrapolation of cardiovascular disease (CVD) risk. A cross-sectional study included 330 participants, subdivided as control (n=110), type 2 DM (n=110) and type 2 DM with CVD groups (n=110). HbA1c, insulin, lipid profile, spexin & leptin including blood pressure and body mass index were analyzed from all the participants. The serum spexin levels (ng/ml) were significantly decreased in type 2 DM (mean ± sd: 0.65 ± 0.03) and type 2 DM with CVD (0.48 ± 0.02) groups compared to the control (0.79 ± 0.03) group (p<0.001). The decreased spexin levels were observed in type 2 DM, and further more decreased in type 2 DM with CVD patients compared to controls indicating that spexin levels could be served as an early prediction of obesity-induced T2DM with CVD risk. |
format | Online Article Text |
id | pubmed-9049087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Biomedical Informatics |
record_format | MEDLINE/PubMed |
spelling | pubmed-90490872022-05-09 Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus Tejaswi, G Dayanand, CD Prabhakar, K Bioinformation Research Article Spexin is novel biomarker, which plays a potential role in glucose and lipid metabolisms. However, there was paucity of serum spexin levels in obesity and diabetes mellitus subjects. Hence the current study was aimed to find the relationship between the serum spexin levels in type 2 Diabetes mellitus (type 2 DM) with extrapolation of cardiovascular disease (CVD) risk. A cross-sectional study included 330 participants, subdivided as control (n=110), type 2 DM (n=110) and type 2 DM with CVD groups (n=110). HbA1c, insulin, lipid profile, spexin & leptin including blood pressure and body mass index were analyzed from all the participants. The serum spexin levels (ng/ml) were significantly decreased in type 2 DM (mean ± sd: 0.65 ± 0.03) and type 2 DM with CVD (0.48 ± 0.02) groups compared to the control (0.79 ± 0.03) group (p<0.001). The decreased spexin levels were observed in type 2 DM, and further more decreased in type 2 DM with CVD patients compared to controls indicating that spexin levels could be served as an early prediction of obesity-induced T2DM with CVD risk. Biomedical Informatics 2021-09-30 /pmc/articles/PMC9049087/ /pubmed/35539887 http://dx.doi.org/10.6026/97320630017790 Text en © 2021 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Research Article Tejaswi, G Dayanand, CD Prabhakar, K Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title | Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title_full | Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title_fullStr | Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title_full_unstemmed | Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title_short | Insulin resistance and decreased spexin in Indian Patients with Type 2 Diabetes Mellitus |
title_sort | insulin resistance and decreased spexin in indian patients with type 2 diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049087/ https://www.ncbi.nlm.nih.gov/pubmed/35539887 http://dx.doi.org/10.6026/97320630017790 |
work_keys_str_mv | AT tejaswig insulinresistanceanddecreasedspexininindianpatientswithtype2diabetesmellitus AT dayanandcd insulinresistanceanddecreasedspexininindianpatientswithtype2diabetesmellitus AT prabhakark insulinresistanceanddecreasedspexininindianpatientswithtype2diabetesmellitus |