Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied usi...

Descripción completa

Detalles Bibliográficos
Autores principales: Palanisamy, Chella Perumal, Pethanan, Sivakumar, Vincent, Gopinath Gurulingam, Murugesan, Karthigeyan, Ramachandran, Ananthavalli, Sivanandam, Ramu, Panagal, Mani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049100/
https://www.ncbi.nlm.nih.gov/pubmed/35540700
http://dx.doi.org/10.6026/97320630017710
_version_ 1784696071047348224
author Palanisamy, Chella Perumal
Pethanan, Sivakumar
Vincent, Gopinath Gurulingam
Murugesan, Karthigeyan
Ramachandran, Ananthavalli
Sivanandam, Ramu
Panagal, Mani
author_facet Palanisamy, Chella Perumal
Pethanan, Sivakumar
Vincent, Gopinath Gurulingam
Murugesan, Karthigeyan
Ramachandran, Ananthavalli
Sivanandam, Ramu
Panagal, Mani
author_sort Palanisamy, Chella Perumal
collection PubMed
description It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in C. trifoliatreated A2780 cell lines for further consideration as a chemotherapeutic agents.
format Online
Article
Text
id pubmed-9049100
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Biomedical Informatics
record_format MEDLINE/PubMed
spelling pubmed-90491002022-05-09 Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells Palanisamy, Chella Perumal Pethanan, Sivakumar Vincent, Gopinath Gurulingam Murugesan, Karthigeyan Ramachandran, Ananthavalli Sivanandam, Ramu Panagal, Mani Bioinformation Research Article It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in C. trifoliatreated A2780 cell lines for further consideration as a chemotherapeutic agents. Biomedical Informatics 2021-08-31 /pmc/articles/PMC9049100/ /pubmed/35540700 http://dx.doi.org/10.6026/97320630017710 Text en © 2021 Biomedical Informatics https://creativecommons.org/licenses/by/3.0/This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
spellingShingle Research Article
Palanisamy, Chella Perumal
Pethanan, Sivakumar
Vincent, Gopinath Gurulingam
Murugesan, Karthigeyan
Ramachandran, Ananthavalli
Sivanandam, Ramu
Panagal, Mani
Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title_full Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title_fullStr Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title_full_unstemmed Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title_short Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells
title_sort chemotherapeutic potential of cayratia trifolia l nhexane extract on a2780 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049100/
https://www.ncbi.nlm.nih.gov/pubmed/35540700
http://dx.doi.org/10.6026/97320630017710
work_keys_str_mv AT palanisamychellaperumal chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT pethanansivakumar chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT vincentgopinathgurulingam chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT murugesankarthigeyan chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT ramachandranananthavalli chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT sivanandamramu chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells
AT panagalmani chemotherapeuticpotentialofcayratiatrifolialnhexaneextractona2780cells

Ejemplares similares