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Design and evaluation of novel thrombin-based GLP-1 analogs with peptidic albumin binding domain for the controlled release of GLP-1

Currently, the curative effects of polypeptide drugs are often restricted due to the short in vivo duration of action. In this study, we fused a series of heptapeptide tags with different length fatty chains to the N-terminus of mutated glucagon-like peptide-1 (GLP-1) using an intermediate sequence...

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Detalles Bibliográficos
Autores principales:	Niu, Xianli, Nong, Shirong, Zhang, Xiaomin, Li, Xiangyang, Wang, Cheng, Li, Wei, Zhou, Tianhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049141/ https://www.ncbi.nlm.nih.gov/pubmed/35495226 http://dx.doi.org/10.1039/d0ra00104j

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