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Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants

BACKGROUND: Transthyretin (TTR), also known as prealbumin, has been suggested as an indicator of protein and nutritional status. OBJECTIVE: The aim of this study was to examine the maternal and umbilical cord (UC) TTR in relation to intrauterine growth, and the serum TTR of preterm infants in relati...

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Autores principales: Habib, Clair, Maor, Irit, Shoris, Irit, Tsuprun, Svetlana, Bader, David, Riskin, Arieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049153/
https://www.ncbi.nlm.nih.gov/pubmed/35482459
http://dx.doi.org/10.5041/RMMJ.10470
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author Habib, Clair
Maor, Irit
Shoris, Irit
Tsuprun, Svetlana
Bader, David
Riskin, Arieh
author_facet Habib, Clair
Maor, Irit
Shoris, Irit
Tsuprun, Svetlana
Bader, David
Riskin, Arieh
author_sort Habib, Clair
collection PubMed
description BACKGROUND: Transthyretin (TTR), also known as prealbumin, has been suggested as an indicator of protein and nutritional status. OBJECTIVE: The aim of this study was to examine the maternal and umbilical cord (UC) TTR in relation to intrauterine growth, and the serum TTR of preterm infants in relation to nutritional status and growth. METHODS: After application of exclusion criteria, 49 preterm infants (mean gestational age and birth-weight 32.9±2.9 weeks and 1822±556 g) were included in the study. Transthyretin was sampled at birth and on days 14, 28, and at discharge with growth parameters and nutritional laboratory test results. RESULTS: Mean UC and maternal TTR were positively correlated (8.5±2.4 mg/dL and 20.4±7.0 mg/dL, r=0.31, P=0.07). Umbilical cord TTR was neither an index of maturity nor of intrauterine growth. Umbilical cord TTR was higher in females (9.4±2.6 versus 7.6±1.8 mg/dL, P=0.015). Maternal TTR was lower in twin pregnancies (16.8±4.9 versus 22.5±7.3 mg/dL, P=0.007). Although TTR levels gradually increased over time in correlation with post-menstrual and chronological ages (r=0.24, P=0.011 and r=0.40, P<0.001, respectively), there was no correlation to weight gain (r=0.10, P=0.41), nutritional status, protein intake, or nutritional laboratory test results. The only significant correlations were between TTR and glucose and triglycerides levels (r=0.51, P<0.001 for both). CONCLUSIONS: Although TTR levels increased over time, we could not demonstrate significant correlations between TTR and indices of the nutritional status in preterm infants at birth or during the neonatal course.
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spelling pubmed-90491532022-04-29 Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants Habib, Clair Maor, Irit Shoris, Irit Tsuprun, Svetlana Bader, David Riskin, Arieh Rambam Maimonides Med J Original Research BACKGROUND: Transthyretin (TTR), also known as prealbumin, has been suggested as an indicator of protein and nutritional status. OBJECTIVE: The aim of this study was to examine the maternal and umbilical cord (UC) TTR in relation to intrauterine growth, and the serum TTR of preterm infants in relation to nutritional status and growth. METHODS: After application of exclusion criteria, 49 preterm infants (mean gestational age and birth-weight 32.9±2.9 weeks and 1822±556 g) were included in the study. Transthyretin was sampled at birth and on days 14, 28, and at discharge with growth parameters and nutritional laboratory test results. RESULTS: Mean UC and maternal TTR were positively correlated (8.5±2.4 mg/dL and 20.4±7.0 mg/dL, r=0.31, P=0.07). Umbilical cord TTR was neither an index of maturity nor of intrauterine growth. Umbilical cord TTR was higher in females (9.4±2.6 versus 7.6±1.8 mg/dL, P=0.015). Maternal TTR was lower in twin pregnancies (16.8±4.9 versus 22.5±7.3 mg/dL, P=0.007). Although TTR levels gradually increased over time in correlation with post-menstrual and chronological ages (r=0.24, P=0.011 and r=0.40, P<0.001, respectively), there was no correlation to weight gain (r=0.10, P=0.41), nutritional status, protein intake, or nutritional laboratory test results. The only significant correlations were between TTR and glucose and triglycerides levels (r=0.51, P<0.001 for both). CONCLUSIONS: Although TTR levels increased over time, we could not demonstrate significant correlations between TTR and indices of the nutritional status in preterm infants at birth or during the neonatal course. Rambam Health Care Campus 2022-04-26 /pmc/articles/PMC9049153/ /pubmed/35482459 http://dx.doi.org/10.5041/RMMJ.10470 Text en © 2022 Habib et al https://creativecommons.org/licenses/by/3.0/This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Habib, Clair
Maor, Irit
Shoris, Irit
Tsuprun, Svetlana
Bader, David
Riskin, Arieh
Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title_full Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title_fullStr Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title_full_unstemmed Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title_short Umbilical Cord and Neonatal Transthyretin and Their Relationship to Growth and Nutrition in Preterm Infants
title_sort umbilical cord and neonatal transthyretin and their relationship to growth and nutrition in preterm infants
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049153/
https://www.ncbi.nlm.nih.gov/pubmed/35482459
http://dx.doi.org/10.5041/RMMJ.10470
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