Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water

A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irr...

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Detalles Bibliográficos
Autores principales: Yu, Zong-Yi, Zhao, Jing-Nan, Yang, Fan, Tang, Xiao-Fei, Wu, Yu-Feng, Ma, Cun-Fei, Song, Bo, Yun, Lei, Meng, Qing-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049176/
https://www.ncbi.nlm.nih.gov/pubmed/35495280
http://dx.doi.org/10.1039/c9ra09227g
Descripción
Sumario:A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irradiation of visible-light and generated corresponding 3-(2-nitroalkyl)indoles in moderate to good yields (up to 87%).

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