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His18 promotes reactive oxidative stress production in copper-ion mediated human islet amyloid polypeptide aggregation

Copper ions play a critical role in human islet amyloid polypeptide (hIAPP) aggregation, which has been found in more than 90% of patients with type-2 diabetes (T2D). The role of Cu(ii) in the cell cytotoxicity with hIAPP has been explored in two aspects: inhibiting the formation of fibrillar struct...

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Detalles Bibliográficos
Autores principales:	Huo, Gengyang, Chen, Wenyong, Wang, Jianhua, Chu, Xinxing, Xu, Wei, Li, Bin, Zhang, Yi, Xu, Binqian, Zhou, Xingfei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049296/ https://www.ncbi.nlm.nih.gov/pubmed/35497413 http://dx.doi.org/10.1039/c9ra09943c

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