Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry

A reliable and sensitive ultra-performance liquid chromatography-tandem mass spectrometry-based method has been developed for the estimation of 4-hydroxyisoleucine (4-HI), a potent insulinotropic and hypolipidemic agent. The extraction of 4-HI from plasma was accomplished by the protein precipitatio...

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Detalles Bibliográficos
Autores principales: Wadhwa, Geetika, Krishna, Kowthavarapu Venkata, Taliyan, Rajeev, Tandon, Neeraj, Yadav, Satyapal Singh, Katiyar, Chandrakant, Dubey, Sunil Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049328/
https://www.ncbi.nlm.nih.gov/pubmed/35497432
http://dx.doi.org/10.1039/c9ra08121f

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