Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro

The fluorinase enzyme represents the only biological mechanism capable of forming stable C–F bonds characterized in nature thus far, offering a biotechnological route to the biosynthesis of value‐added organofluorines. The fluorinase is known to operate in a hexameric form, but the consequence(s) of...

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Detalles Bibliográficos
Autores principales: Kittilä, Tiia, Calero, Patricia, Fredslund, Folmer, Lowe, Phillip T., Tezé, David, Nieto‐Domínguez, Manuel, O’Hagan, David, Nikel, Pablo I., Welner, Ditte H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Engineering Biology and Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049626/
https://www.ncbi.nlm.nih.gov/pubmed/35084776
http://dx.doi.org/10.1111/1751-7915.14009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049626/
https://www.ncbi.nlm.nih.gov/pubmed/35084776
http://dx.doi.org/10.1111/1751-7915.14009

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