Cargando…
The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds
Calcium phosphate based biomaterials have been widely studied in biomedical areas. Herein, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods were separately prepared and used for coating tantalum (Ta) scaffolds with a polymer of polylactide (PLA). We have found that diff...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049840/ https://www.ncbi.nlm.nih.gov/pubmed/35492178 http://dx.doi.org/10.1039/c9ra09385k |
_version_ | 1784696230717161472 |
---|---|
author | Zhou, Rong Ni, Hai-Jian Peng, Jin-Hui Liu, Ning Chen, Shu Shao, Jia-Hua Fu, Qi-Wei Liu, Jun-Jian Chen, Feng Qian, Qi-Rong |
author_facet | Zhou, Rong Ni, Hai-Jian Peng, Jin-Hui Liu, Ning Chen, Shu Shao, Jia-Hua Fu, Qi-Wei Liu, Jun-Jian Chen, Feng Qian, Qi-Rong |
author_sort | Zhou, Rong |
collection | PubMed |
description | Calcium phosphate based biomaterials have been widely studied in biomedical areas. Herein, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods were separately prepared and used for coating tantalum (Ta) scaffolds with a polymer of polylactide (PLA). We have found that different crystal phases of calcium phosphate coated on Ta scaffolds displayed different effects on the surface morphologies, mineralization and bovine serum albumin (BSA) release. The ACP-PLA and HA-PLA coated on Ta scaffold were more favorable for in vitro mineralization than bare and PLA coated Ta scaffolds, and resulted in a highly hydrophilic surfaces. Meanwhile, the osteoblast-like cells (MG63) showed favorable properties of adhesion and spreading on both ACP-PLA and HA-PLA coated Ta scaffolds. The ACP-PLA and HA-PLA coated Ta scaffolds showed a high biocompatibility and potential applications for in vivo bone defect repair. |
format | Online Article Text |
id | pubmed-9049840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90498402022-04-29 The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds Zhou, Rong Ni, Hai-Jian Peng, Jin-Hui Liu, Ning Chen, Shu Shao, Jia-Hua Fu, Qi-Wei Liu, Jun-Jian Chen, Feng Qian, Qi-Rong RSC Adv Chemistry Calcium phosphate based biomaterials have been widely studied in biomedical areas. Herein, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods were separately prepared and used for coating tantalum (Ta) scaffolds with a polymer of polylactide (PLA). We have found that different crystal phases of calcium phosphate coated on Ta scaffolds displayed different effects on the surface morphologies, mineralization and bovine serum albumin (BSA) release. The ACP-PLA and HA-PLA coated on Ta scaffold were more favorable for in vitro mineralization than bare and PLA coated Ta scaffolds, and resulted in a highly hydrophilic surfaces. Meanwhile, the osteoblast-like cells (MG63) showed favorable properties of adhesion and spreading on both ACP-PLA and HA-PLA coated Ta scaffolds. The ACP-PLA and HA-PLA coated Ta scaffolds showed a high biocompatibility and potential applications for in vivo bone defect repair. The Royal Society of Chemistry 2020-02-21 /pmc/articles/PMC9049840/ /pubmed/35492178 http://dx.doi.org/10.1039/c9ra09385k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Zhou, Rong Ni, Hai-Jian Peng, Jin-Hui Liu, Ning Chen, Shu Shao, Jia-Hua Fu, Qi-Wei Liu, Jun-Jian Chen, Feng Qian, Qi-Rong The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title | The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title_full | The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title_fullStr | The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title_full_unstemmed | The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title_short | The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds |
title_sort | mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/pla modified tantalum scaffolds |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049840/ https://www.ncbi.nlm.nih.gov/pubmed/35492178 http://dx.doi.org/10.1039/c9ra09385k |
work_keys_str_mv | AT zhourong themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT nihaijian themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT pengjinhui themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT liuning themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT chenshu themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT shaojiahua themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT fuqiwei themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT liujunjian themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT chenfeng themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT qianqirong themineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT zhourong mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT nihaijian mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT pengjinhui mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT liuning mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT chenshu mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT shaojiahua mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT fuqiwei mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT liujunjian mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT chenfeng mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds AT qianqirong mineralizationdrugreleaseandinvivobonedefectrepairpropertiesofcalciumphosphatesplamodifiedtantalumscaffolds |