Palladium-catalysed difluoroolefination of benzyl tosylates toward the synthesis of gem-difluoro-2-trifluromethyl styrene derivatives

We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram–scale reactions demonstrated the robustness and potential of this me...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Liu, Jiangjun, Chen, Gang, Xiong, Baojian, Zhang, Xuemei, Lian, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049850/
https://www.ncbi.nlm.nih.gov/pubmed/35497019
http://dx.doi.org/10.1039/d2ra02473j
Descripción
Sumario:We have presented an efficient method to access gem-difluoro-2-trifluromethyl styrene derivatives via palladium catalysis. This method features mild reaction conditions, broad substrate scope and good product yields. Moreover, gram–scale reactions demonstrated the robustness and potential of this method. Control experiments revealed that the –CF(3) group was essential to the success of this transformation. Finally, the practicality of this method was successfully proven by three synthetic applications.

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