Newly synthesized 3-(4-chloro-phenyl)-3-hydroxy-2,2-dimethyl-propionic acid methyl ester derivatives selectively inhibit the proliferation of colon cancer cells

A series of 24 compounds were synthesized based on structure modification of the model methyl-3-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropanoate as potent HDACIs. Saponification and hydrazinolysis of the model ester afforded the corresponding acid and hydrazide, respectively. The model ester was tr...

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Detalles Bibliográficos
Autores principales: El Rayes, Samir M., Aboelmagd, Ahmed, Gomaa, Mohamed S., Fathalla, Walid, Ali, Ibrahim A. I., Pottoo, Faheem H., Khan, Firdos Alam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049988/
https://www.ncbi.nlm.nih.gov/pubmed/35496560
http://dx.doi.org/10.1039/c9ra10950a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049988/
https://www.ncbi.nlm.nih.gov/pubmed/35496560
http://dx.doi.org/10.1039/c9ra10950a

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