Cargando…
Catalytic, selective, and stereocontrolled construction of C4 quaternary and homobenzylic dihydroisoquinolones by sp(3) C–H benzylation
C1 benzylated isoquinoline derivatives constitute the core of benzylisoquinoline alkaloids (BIAs). However, their C4 congeners remain elusive. Here, we describe a diastereoselective, catalytic, and modular C(sp(3))–C(sp(3)) coupling protocol wherein β-amino sp(3) C–H bonds of readily affordable vici...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050025/ https://www.ncbi.nlm.nih.gov/pubmed/35496534 http://dx.doi.org/10.1039/c9ra10888b |