Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives

A simple and original efficient synthesis of 3-amino-1H-isochromene bearing a bromine atom at the C-1 position via a 6-endo-cyclization approach from in situ generated ortho-ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and with good yields. Original ortho-ynamid...

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Detalles Bibliográficos
Autores principales: Habert, Loïc, Diachenko, Iryna, Gillaizeau, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050208/
https://www.ncbi.nlm.nih.gov/pubmed/35498568
http://dx.doi.org/10.1039/d0ra00768d
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author Habert, Loïc
Diachenko, Iryna
Gillaizeau, Isabelle
author_facet Habert, Loïc
Diachenko, Iryna
Gillaizeau, Isabelle
author_sort Habert, Loïc
collection PubMed
description A simple and original efficient synthesis of 3-amino-1H-isochromene bearing a bromine atom at the C-1 position via a 6-endo-cyclization approach from in situ generated ortho-ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and with good yields. Original ortho-ynamidyl benzaldehyde compounds were also successfully obtained.
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spelling pubmed-90502082022-04-29 Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives Habert, Loïc Diachenko, Iryna Gillaizeau, Isabelle RSC Adv Chemistry A simple and original efficient synthesis of 3-amino-1H-isochromene bearing a bromine atom at the C-1 position via a 6-endo-cyclization approach from in situ generated ortho-ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and with good yields. Original ortho-ynamidyl benzaldehyde compounds were also successfully obtained. The Royal Society of Chemistry 2020-03-10 /pmc/articles/PMC9050208/ /pubmed/35498568 http://dx.doi.org/10.1039/d0ra00768d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Habert, Loïc
Diachenko, Iryna
Gillaizeau, Isabelle
Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title_full Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title_fullStr Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title_full_unstemmed Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title_short Rapid synthesis of 3-amino-1H-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
title_sort rapid synthesis of 3-amino-1h-isochromene from ortho-ynamidyl het(aryl) aldehyde derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050208/
https://www.ncbi.nlm.nih.gov/pubmed/35498568
http://dx.doi.org/10.1039/d0ra00768d
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