Non-cytotoxic, temperature-responsive and antibacterial POEGMA based nanocomposite coatings with silver nanoparticles

Non-cytotoxic, temperature-responsive and antibacterial poly(di(ethylene glycol)methyl ether methacrylate) – POEGMA188 based nanocomposite coatings attached to a glass surface were successfully prepared using ATRP polymerization. The thickness, morphology and wettability of the resulting coatings we...

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Detalles Bibliográficos
Autores principales: Nastyshyn, Svyatoslav, Raczkowska, Joanna, Stetsyshyn, Yurij, Orzechowska, Barbara, Bernasik, Andrzej, Shymborska, Yana, Brzychczy-Włoch, Monika, Gosiewski, Tomasz, Lishchynskyi, Ostap, Ohar, Halyna, Ochońska, Dorota, Awsiuk, Kamil, Budkowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050227/
https://www.ncbi.nlm.nih.gov/pubmed/35498562
http://dx.doi.org/10.1039/c9ra10874b
Descripción
Sumario:Non-cytotoxic, temperature-responsive and antibacterial poly(di(ethylene glycol)methyl ether methacrylate) – POEGMA188 based nanocomposite coatings attached to a glass surface were successfully prepared using ATRP polymerization. The thickness, morphology and wettability of the resulting coatings were analyzed using ellipsometry, AFM and contact angle measurements, respectively. The strong impact of the thicknesses of the POEGMA188 grafted brush coatings and content of AgNPs on the morphology and temperature-induced wettability changes of the nanocomposite was demonstrated. In addition to the strong temperature-dependent antibacterial activity, the proposed nanocomposite coatings have no significant cytotoxic effect towards normal cells. Moreover, the slight anti-cancer effect of AgNPs may be suggested.

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