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Placental Tissues as Biomaterials in Regenerative Medicine

Placental tissues encompass all the tissues which support fetal development, including the placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has been renewed interest in the use of these tissues as a raw material for regenerative medicine applications. Placental...

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Detalles Bibliográficos
Autores principales: Roy, Annelise, Mantay, Morgan, Brannan, Courtney, Griffiths, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050314/
https://www.ncbi.nlm.nih.gov/pubmed/35496035
http://dx.doi.org/10.1155/2022/6751456
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author Roy, Annelise
Mantay, Morgan
Brannan, Courtney
Griffiths, Sarah
author_facet Roy, Annelise
Mantay, Morgan
Brannan, Courtney
Griffiths, Sarah
author_sort Roy, Annelise
collection PubMed
description Placental tissues encompass all the tissues which support fetal development, including the placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has been renewed interest in the use of these tissues as a raw material for regenerative medicine applications. Placental tissues have been extensively studied for their potential contribution to tissue repair applications. Studies have attributed their efficacy in augmenting the healing process to the extracellular matrix scaffolds rich in collagens, glycosaminoglycans, and proteoglycans, as well as the presence of cytokines within the tissues that have been shown to stimulate re-epithelialization, promote angiogenesis, and aid in the reduction of inflammation and scarring. The compositions and properties of all birth tissues give them the potential to be valuable biomaterials for the development of new regenerative therapies. Herein, the development and compositions of each of these tissues are reviewed, with focus on the structural and signaling components that are relevant to medical applications. This review also explores current configurations and recent innovations in the use of placental tissues as biomaterials in regenerative medicine.
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spelling pubmed-90503142022-04-29 Placental Tissues as Biomaterials in Regenerative Medicine Roy, Annelise Mantay, Morgan Brannan, Courtney Griffiths, Sarah Biomed Res Int Review Article Placental tissues encompass all the tissues which support fetal development, including the placenta, placental membrane, umbilical cord, and amniotic fluid. Since the 1990s there has been renewed interest in the use of these tissues as a raw material for regenerative medicine applications. Placental tissues have been extensively studied for their potential contribution to tissue repair applications. Studies have attributed their efficacy in augmenting the healing process to the extracellular matrix scaffolds rich in collagens, glycosaminoglycans, and proteoglycans, as well as the presence of cytokines within the tissues that have been shown to stimulate re-epithelialization, promote angiogenesis, and aid in the reduction of inflammation and scarring. The compositions and properties of all birth tissues give them the potential to be valuable biomaterials for the development of new regenerative therapies. Herein, the development and compositions of each of these tissues are reviewed, with focus on the structural and signaling components that are relevant to medical applications. This review also explores current configurations and recent innovations in the use of placental tissues as biomaterials in regenerative medicine. Hindawi 2022-04-21 /pmc/articles/PMC9050314/ /pubmed/35496035 http://dx.doi.org/10.1155/2022/6751456 Text en Copyright © 2022 Annelise Roy et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Roy, Annelise
Mantay, Morgan
Brannan, Courtney
Griffiths, Sarah
Placental Tissues as Biomaterials in Regenerative Medicine
title Placental Tissues as Biomaterials in Regenerative Medicine
title_full Placental Tissues as Biomaterials in Regenerative Medicine
title_fullStr Placental Tissues as Biomaterials in Regenerative Medicine
title_full_unstemmed Placental Tissues as Biomaterials in Regenerative Medicine
title_short Placental Tissues as Biomaterials in Regenerative Medicine
title_sort placental tissues as biomaterials in regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050314/
https://www.ncbi.nlm.nih.gov/pubmed/35496035
http://dx.doi.org/10.1155/2022/6751456
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