Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis

Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterizat...

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Autores principales: Mehdipour Dalivand, Maryam, Tizro, Parastou, Partain, Julie, Aggarwal, Anita, Lichy, Jack, Mot Ara, Francisco, Nava, Victor E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050327/
https://www.ncbi.nlm.nih.gov/pubmed/35495178
http://dx.doi.org/10.1155/2022/1132544
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author Mehdipour Dalivand, Maryam
Tizro, Parastou
Partain, Julie
Aggarwal, Anita
Lichy, Jack
Mot Ara, Francisco
Nava, Victor E.
author_facet Mehdipour Dalivand, Maryam
Tizro, Parastou
Partain, Julie
Aggarwal, Anita
Lichy, Jack
Mot Ara, Francisco
Nava, Victor E.
author_sort Mehdipour Dalivand, Maryam
collection PubMed
description Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.
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spelling pubmed-90503272022-04-29 Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis Mehdipour Dalivand, Maryam Tizro, Parastou Partain, Julie Aggarwal, Anita Lichy, Jack Mot Ara, Francisco Nava, Victor E. Case Rep Hematol Case Report Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms. Hindawi 2022-04-21 /pmc/articles/PMC9050327/ /pubmed/35495178 http://dx.doi.org/10.1155/2022/1132544 Text en Copyright © 2022 Maryam Mehdipour Dalivand et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Mehdipour Dalivand, Maryam
Tizro, Parastou
Partain, Julie
Aggarwal, Anita
Lichy, Jack
Mot Ara, Francisco
Nava, Victor E.
Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title_full Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title_fullStr Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title_full_unstemmed Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title_short Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
title_sort concurrent b cell acute lymphoblastic lymphoma/leukemia and monoclonal b cell lymphocytosis: a case report with extensive molecular analysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050327/
https://www.ncbi.nlm.nih.gov/pubmed/35495178
http://dx.doi.org/10.1155/2022/1132544
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