Blocking TGF-β Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils

In the tumor microenvironment (TME), cells secrete a cytokine known as transforming growth factor-β (TGF-β), which polarizes tumor-associated neutrophils (TANs) towards a protumor phenotype. In this work, C57BL/6 mice with TGF-β1 gene knocked out selectively in myofibroblasts receive orthotopic impl...

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Detalles Bibliográficos
Autores principales: Fang, Yifei, Li, Xiyao, Jiang, Yuxuan, Ge, Zhihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050332/
https://www.ncbi.nlm.nih.gov/pubmed/35498537
http://dx.doi.org/10.1155/2022/3447185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050332/
https://www.ncbi.nlm.nih.gov/pubmed/35498537
http://dx.doi.org/10.1155/2022/3447185

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