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Blocking TGF-β Expression Attenuates Tumor Growth in Lung Cancers, Potentially Mediated by Skewing Development of Neutrophils
In the tumor microenvironment (TME), cells secrete a cytokine known as transforming growth factor-β (TGF-β), which polarizes tumor-associated neutrophils (TANs) towards a protumor phenotype. In this work, C57BL/6 mice with TGF-β1 gene knocked out selectively in myofibroblasts receive orthotopic impl...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050332/ https://www.ncbi.nlm.nih.gov/pubmed/35498537 http://dx.doi.org/10.1155/2022/3447185 |