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Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050354/ https://www.ncbi.nlm.nih.gov/pubmed/35492613 http://dx.doi.org/10.3389/fphys.2022.834077 |
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author | Meng, Xiang-Long Yu, Mu-Ming Liu, Yan-Cun Gao, Yu-Lei Chen, Xin-Sen Shou, Song-Tao Chai, Yan-Fen |
author_facet | Meng, Xiang-Long Yu, Mu-Ming Liu, Yan-Cun Gao, Yu-Lei Chen, Xin-Sen Shou, Song-Tao Chai, Yan-Fen |
author_sort | Meng, Xiang-Long |
collection | PubMed |
description | Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis. |
format | Online Article Text |
id | pubmed-9050354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90503542022-04-29 Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy Meng, Xiang-Long Yu, Mu-Ming Liu, Yan-Cun Gao, Yu-Lei Chen, Xin-Sen Shou, Song-Tao Chai, Yan-Fen Front Physiol Physiology Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9050354/ /pubmed/35492613 http://dx.doi.org/10.3389/fphys.2022.834077 Text en Copyright © 2022 Meng, Yu, Liu, Gao, Chen, Shou and Chai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Meng, Xiang-Long Yu, Mu-Ming Liu, Yan-Cun Gao, Yu-Lei Chen, Xin-Sen Shou, Song-Tao Chai, Yan-Fen Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title | Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title_full | Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title_fullStr | Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title_full_unstemmed | Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title_short | Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy |
title_sort | rutin inhibits cardiac apoptosis and prevents sepsis-induced cardiomyopathy |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050354/ https://www.ncbi.nlm.nih.gov/pubmed/35492613 http://dx.doi.org/10.3389/fphys.2022.834077 |
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