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Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy

Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopa...

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Autores principales: Meng, Xiang-Long, Yu, Mu-Ming, Liu, Yan-Cun, Gao, Yu-Lei, Chen, Xin-Sen, Shou, Song-Tao, Chai, Yan-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050354/
https://www.ncbi.nlm.nih.gov/pubmed/35492613
http://dx.doi.org/10.3389/fphys.2022.834077
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author Meng, Xiang-Long
Yu, Mu-Ming
Liu, Yan-Cun
Gao, Yu-Lei
Chen, Xin-Sen
Shou, Song-Tao
Chai, Yan-Fen
author_facet Meng, Xiang-Long
Yu, Mu-Ming
Liu, Yan-Cun
Gao, Yu-Lei
Chen, Xin-Sen
Shou, Song-Tao
Chai, Yan-Fen
author_sort Meng, Xiang-Long
collection PubMed
description Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis.
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spelling pubmed-90503542022-04-29 Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy Meng, Xiang-Long Yu, Mu-Ming Liu, Yan-Cun Gao, Yu-Lei Chen, Xin-Sen Shou, Song-Tao Chai, Yan-Fen Front Physiol Physiology Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide rutinose, which has been reported to exert various biological effects such as antioxidant and anti-inflammatory activities. It is not clear whether rutin has a protective effect on sepsis-induced cardiomyopathy (SIC). In this study, we used male C57BL/6 mice and cecal ligation and puncture (CLP) surgery to establish the model of SIC. Rutin was precautionarily treated (50, 100, 200 mg/kg per day, 7 days) before CLP. The results showed that rutin pretreatment (100, 200 mg/kg per day, 7 days) reduced the mortality of murine sepsis. We chose the 100 mg/kg dose for further studies. Mice were pretreatment with rutin (100 mg/kg per day, 7 days) before subjected to CLP, and myocardial tissue and blood samples were collected 24 h after CLP. Serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and cTNT decreased, while interleukin-10 (IL-10) increased with rutin pretreatment. The cardiomyocytes apoptosis and mitochondrial dysfunction were also alleviated with rutin pretreatment. In conclusion, this study confirmed the efficacy of rutin-enriched diet in the prophylaxis of cardiac apoptosis and cardiac injury induced by CLP in mouse model. It provides a potential new approach on SIC prophylaxis in sepsis. Frontiers Media S.A. 2022-04-14 /pmc/articles/PMC9050354/ /pubmed/35492613 http://dx.doi.org/10.3389/fphys.2022.834077 Text en Copyright © 2022 Meng, Yu, Liu, Gao, Chen, Shou and Chai. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Meng, Xiang-Long
Yu, Mu-Ming
Liu, Yan-Cun
Gao, Yu-Lei
Chen, Xin-Sen
Shou, Song-Tao
Chai, Yan-Fen
Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title_full Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title_fullStr Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title_full_unstemmed Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title_short Rutin Inhibits Cardiac Apoptosis and Prevents Sepsis-Induced Cardiomyopathy
title_sort rutin inhibits cardiac apoptosis and prevents sepsis-induced cardiomyopathy
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050354/
https://www.ncbi.nlm.nih.gov/pubmed/35492613
http://dx.doi.org/10.3389/fphys.2022.834077
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