Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, re...

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Detalles Bibliográficos
Autores principales: Fu, Yajie, Lu, Zeping, Fang, Ke, He, Xinyi, Xu, Huajin, Hu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050360/
https://www.ncbi.nlm.nih.gov/pubmed/35492907
http://dx.doi.org/10.1039/c9ra10014h
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author Fu, Yajie
Lu, Zeping
Fang, Ke
He, Xinyi
Xu, Huajin
Hu, Yi
author_facet Fu, Yajie
Lu, Zeping
Fang, Ke
He, Xinyi
Xu, Huajin
Hu, Yi
author_sort Fu, Yajie
collection PubMed
description A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.
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spelling pubmed-90503602022-04-29 Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water Fu, Yajie Lu, Zeping Fang, Ke He, Xinyi Xu, Huajin Hu, Yi RSC Adv Chemistry A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up. The Royal Society of Chemistry 2020-03-16 /pmc/articles/PMC9050360/ /pubmed/35492907 http://dx.doi.org/10.1039/c9ra10014h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Fu, Yajie
Lu, Zeping
Fang, Ke
He, Xinyi
Xu, Huajin
Hu, Yi
Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title_full Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title_fullStr Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title_full_unstemmed Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title_short Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
title_sort enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050360/
https://www.ncbi.nlm.nih.gov/pubmed/35492907
http://dx.doi.org/10.1039/c9ra10014h
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AT hexinyi enzymaticapproachtocascadesynthesisofbisindolylmethanesinpurewater
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