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Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines

A new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Brønsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization...

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Detalles Bibliográficos
Autores principales:	Shcherbakov, Stanislav S., Magometov, Artyom Yu., Shcherbakova, Viktoriia Yu., Aksenov, Alexander V., Domenyuk, Dmitriy A., Zelensky, Vladimir A., Rubin, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050372/ https://www.ncbi.nlm.nih.gov/pubmed/35498620 http://dx.doi.org/10.1039/d0ra01335h

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