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Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination

PURPOSE: The primary objective of the current study is to determine whether bariatric surgery reversed the negative impact of obesity on the serological response after the COVID-19 vaccination. This objective is achieved in two steps: (a) quantifying the negative impact of obesity on the serological...

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Autores principales: Hany, Mohamed, Torensma, Bart, Abouelnasr, Anwar Ashraf, Zidan, Ahmed, Ibrahim, Mohamed, Agayby, Ann Samy Shafiq, Hesham, Mohamed, Elsheredy, Amel, Abu-Sheasha, Ghada Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050480/
https://www.ncbi.nlm.nih.gov/pubmed/35486149
http://dx.doi.org/10.1007/s00423-022-02516-6
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author Hany, Mohamed
Torensma, Bart
Abouelnasr, Anwar Ashraf
Zidan, Ahmed
Ibrahim, Mohamed
Agayby, Ann Samy Shafiq
Hesham, Mohamed
Elsheredy, Amel
Abu-Sheasha, Ghada Ahmed
author_facet Hany, Mohamed
Torensma, Bart
Abouelnasr, Anwar Ashraf
Zidan, Ahmed
Ibrahim, Mohamed
Agayby, Ann Samy Shafiq
Hesham, Mohamed
Elsheredy, Amel
Abu-Sheasha, Ghada Ahmed
author_sort Hany, Mohamed
collection PubMed
description PURPOSE: The primary objective of the current study is to determine whether bariatric surgery reversed the negative impact of obesity on the serological response after the COVID-19 vaccination. This objective is achieved in two steps: (a) quantifying the negative impact of obesity on the serological response after COVID-19 vaccination if it is present, and (b) testing whether bariatric surgery reversed this impact. The secondary objective was to monitor the occurrence of adverse events. METHODS: This is a prospective cohort study between May 2021 and August 2021 on the strength of serological response after COVID-19 vaccination. Patients were classified into three groups. Group A (controls with normal or overweight), Group B (bariatric patients pre-operative), and Group C (bariatric patients post-operative). Quantitative antibodies against SARS‑CoV‑2 RBD with a strong neutralizing capacity were quantified from sera after at least 2 weeks post-vaccination. RESULTS: Of the 276 participants, Group A had n = 73, Group B had n = 126, and Group C had n = 77 patients. Overall, a strongly positive vaccine serological response was observed among 86% in group A, 63% in Group B, and 88% in Group C. Group C showed 5.33 times [95% CI 2.15 to 13.18] higher immune response than group B. Mild to moderate adverse events occurred in 30.1% [95% CI 24.7 to 35.9] of the study samples. Adverse events with the whole virus, mRNA, and vector vaccines occurred in 25%, 28%, and 37%, respectively. CONCLUSION: Vaccinating and bariatric surgery are safe and effective treatments in the serological response in patients who suffer from obesity.
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spelling pubmed-90504802022-04-29 Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination Hany, Mohamed Torensma, Bart Abouelnasr, Anwar Ashraf Zidan, Ahmed Ibrahim, Mohamed Agayby, Ann Samy Shafiq Hesham, Mohamed Elsheredy, Amel Abu-Sheasha, Ghada Ahmed Langenbecks Arch Surg Original Article PURPOSE: The primary objective of the current study is to determine whether bariatric surgery reversed the negative impact of obesity on the serological response after the COVID-19 vaccination. This objective is achieved in two steps: (a) quantifying the negative impact of obesity on the serological response after COVID-19 vaccination if it is present, and (b) testing whether bariatric surgery reversed this impact. The secondary objective was to monitor the occurrence of adverse events. METHODS: This is a prospective cohort study between May 2021 and August 2021 on the strength of serological response after COVID-19 vaccination. Patients were classified into three groups. Group A (controls with normal or overweight), Group B (bariatric patients pre-operative), and Group C (bariatric patients post-operative). Quantitative antibodies against SARS‑CoV‑2 RBD with a strong neutralizing capacity were quantified from sera after at least 2 weeks post-vaccination. RESULTS: Of the 276 participants, Group A had n = 73, Group B had n = 126, and Group C had n = 77 patients. Overall, a strongly positive vaccine serological response was observed among 86% in group A, 63% in Group B, and 88% in Group C. Group C showed 5.33 times [95% CI 2.15 to 13.18] higher immune response than group B. Mild to moderate adverse events occurred in 30.1% [95% CI 24.7 to 35.9] of the study samples. Adverse events with the whole virus, mRNA, and vector vaccines occurred in 25%, 28%, and 37%, respectively. CONCLUSION: Vaccinating and bariatric surgery are safe and effective treatments in the serological response in patients who suffer from obesity. Springer Berlin Heidelberg 2022-04-29 2022 /pmc/articles/PMC9050480/ /pubmed/35486149 http://dx.doi.org/10.1007/s00423-022-02516-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Hany, Mohamed
Torensma, Bart
Abouelnasr, Anwar Ashraf
Zidan, Ahmed
Ibrahim, Mohamed
Agayby, Ann Samy Shafiq
Hesham, Mohamed
Elsheredy, Amel
Abu-Sheasha, Ghada Ahmed
Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title_full Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title_fullStr Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title_full_unstemmed Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title_short Impact of bariatric surgery on the effectiveness of serological response after COVID-19 vaccination
title_sort impact of bariatric surgery on the effectiveness of serological response after covid-19 vaccination
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050480/
https://www.ncbi.nlm.nih.gov/pubmed/35486149
http://dx.doi.org/10.1007/s00423-022-02516-6
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