Design, synthesis and biological evaluation of novel amide-linked 18β-glycyrrhetinic acid derivatives as novel ALK inhibitors

A series of novel amide-linked 18β-glycyrrhetinic acid derivatives were developed by incorporating substituted piperazine amide fragments into the C30–COOH of 18β-glycyrrhetinic acid scaffold. The synthesized compounds were evaluated for their anticancer activity against Karpas299, A549, HepG2, MCF-...

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Detalles Bibliográficos
Autores principales: Cai, Dong, Zhang, Zhi hua, Chen, Yu, Ruan, Chao, Li, Sheng qiang, Chen, Shi qin, Chen, Lian shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050490/
https://www.ncbi.nlm.nih.gov/pubmed/35496614
http://dx.doi.org/10.1039/d0ra00681e

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