Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy

Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotos...

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Detalles Bibliográficos
Autores principales: Lu, Xiaomei, Song, Xingwen, Wang, Qi, Hu, Wenbo, Shi, Wei, Tang, Yufu, Wu, Zizi, Fan, Quli, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050500/
https://www.ncbi.nlm.nih.gov/pubmed/35496588
http://dx.doi.org/10.1039/d0ra01477j
Descripción
Sumario:Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.

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