Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings

A variety of N-unprotected 2-amide-substituted indoles were synthesized from readily available furfural-based Ugi adducts in moderate to good yields via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings. These reactions involved a cascade sequence consisting of dea...

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Detalles Bibliográficos
Autores principales: Peng, Hui, Jiang, Kai, Zhen, Guangjin, Wang, Furong, Yin, Biaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050509/
https://www.ncbi.nlm.nih.gov/pubmed/35496608
http://dx.doi.org/10.1039/d0ra01830a
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author Peng, Hui
Jiang, Kai
Zhen, Guangjin
Wang, Furong
Yin, Biaolin
author_facet Peng, Hui
Jiang, Kai
Zhen, Guangjin
Wang, Furong
Yin, Biaolin
author_sort Peng, Hui
collection PubMed
description A variety of N-unprotected 2-amide-substituted indoles were synthesized from readily available furfural-based Ugi adducts in moderate to good yields via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings. These reactions involved a cascade sequence consisting of dearomatizing arylation, opening of the furan ring, and deprotection of the N atom.
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spelling pubmed-90505092022-04-29 Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings Peng, Hui Jiang, Kai Zhen, Guangjin Wang, Furong Yin, Biaolin RSC Adv Chemistry A variety of N-unprotected 2-amide-substituted indoles were synthesized from readily available furfural-based Ugi adducts in moderate to good yields via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings. These reactions involved a cascade sequence consisting of dearomatizing arylation, opening of the furan ring, and deprotection of the N atom. The Royal Society of Chemistry 2020-03-23 /pmc/articles/PMC9050509/ /pubmed/35496608 http://dx.doi.org/10.1039/d0ra01830a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Peng, Hui
Jiang, Kai
Zhen, Guangjin
Wang, Furong
Yin, Biaolin
Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title_full Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title_fullStr Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title_full_unstemmed Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title_short Access to N-unprotected 2-amide-substituted indoles from Ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
title_sort access to n-unprotected 2-amide-substituted indoles from ugi adducts via palladium-catalyzed intramolecular cyclization of o-iodoanilines bearing furan rings
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050509/
https://www.ncbi.nlm.nih.gov/pubmed/35496608
http://dx.doi.org/10.1039/d0ra01830a
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