MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis

Aberrant expression of MYC transcription factor family members predicts poor clinical outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an antioxidant response to maintain redox balance. Here we show that MYCN induces massive lipid peroxidation on depletion of cy...

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Detalles Bibliográficos
Autores principales: Alborzinia, Hamed, Flórez, Andrés F., Kreth, Sina, Brückner, Lena M., Yildiz, Umut, Gartlgruber, Moritz, Odoni, Dorett I., Poschet, Gernot, Garbowicz, Karolina, Shao, Chunxuan, Klein, Corinna, Meier, Jasmin, Zeisberger, Petra, Nadler-Holly, Michal, Ziehm, Matthias, Paul, Franziska, Burhenne, Jürgen, Bell, Emma, Shaikhkarami, Marjan, Würth, Roberto, Stainczyk, Sabine A., Wecht, Elisa M., Kreth, Jochen, Büttner, Michael, Ishaque, Naveed, Schlesner, Matthias, Nicke, Barbara, Stresemann, Carlo, Llamazares-Prada, María, Reiling, Jan H., Fischer, Matthias, Amit, Ido, Selbach, Matthias, Herrmann, Carl, Wölfl, Stefan, Henrich, Kai-Oliver, Höfer, Thomas, Trumpp, Andreas, Westermann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050595/
https://www.ncbi.nlm.nih.gov/pubmed/35484422
http://dx.doi.org/10.1038/s43018-022-00355-4

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