Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives

A series of 2-anilinopyrimidines including novel derivatives has been obtained from 2-chloro-4,6-dimethylpyrimidine by aromatic nucleophilic substitution with differently substituted anilines under microwave conditions. The substituents had a significant impact on the course and efficiency of the re...

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Autores principales: Campestre, Cristina, Keglevich, György, Kóti, János, Scotti, Luca, Gasbarri, Carla, Angelini, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050660/
https://www.ncbi.nlm.nih.gov/pubmed/35497585
http://dx.doi.org/10.1039/d0ra00833h
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author Campestre, Cristina
Keglevich, György
Kóti, János
Scotti, Luca
Gasbarri, Carla
Angelini, Guido
author_facet Campestre, Cristina
Keglevich, György
Kóti, János
Scotti, Luca
Gasbarri, Carla
Angelini, Guido
author_sort Campestre, Cristina
collection PubMed
description A series of 2-anilinopyrimidines including novel derivatives has been obtained from 2-chloro-4,6-dimethylpyrimidine by aromatic nucleophilic substitution with differently substituted anilines under microwave conditions. The substituents had a significant impact on the course and efficiency of the reaction. The results reported herein demonstrate the efficacy of microwaves in the synthesis of the title heterocyclic compounds as compared to the results obtained with conventional heating. The 2-anilinopyrimidines described are of potential bioactivity.
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spelling pubmed-90506602022-04-29 Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives Campestre, Cristina Keglevich, György Kóti, János Scotti, Luca Gasbarri, Carla Angelini, Guido RSC Adv Chemistry A series of 2-anilinopyrimidines including novel derivatives has been obtained from 2-chloro-4,6-dimethylpyrimidine by aromatic nucleophilic substitution with differently substituted anilines under microwave conditions. The substituents had a significant impact on the course and efficiency of the reaction. The results reported herein demonstrate the efficacy of microwaves in the synthesis of the title heterocyclic compounds as compared to the results obtained with conventional heating. The 2-anilinopyrimidines described are of potential bioactivity. The Royal Society of Chemistry 2020-03-25 /pmc/articles/PMC9050660/ /pubmed/35497585 http://dx.doi.org/10.1039/d0ra00833h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Campestre, Cristina
Keglevich, György
Kóti, János
Scotti, Luca
Gasbarri, Carla
Angelini, Guido
Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title_full Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title_fullStr Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title_full_unstemmed Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title_short Microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
title_sort microwave-assisted simple synthesis of 2-anilinopyrimidines by the reaction of 2-chloro-4,6-dimethylpyrimidine with aniline derivatives
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050660/
https://www.ncbi.nlm.nih.gov/pubmed/35497585
http://dx.doi.org/10.1039/d0ra00833h
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