TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance

Pathways that direct the selection of the telomerase-dependent or recombination-based, alternative lengthening of telomere (ALT) maintenance pathway in cancer cells are poorly understood. Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) c...

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Detalles Bibliográficos
Autores principales: Buemi, Valentina, Schillaci, Odessa, Santorsola, Mariangela, Bonazza, Deborah, Broccia, Pamela Veneziano, Zappone, Annie, Bottin, Cristina, Dell’Omo, Giulia, Kengne, Sylvie, Cacchione, Stefano, Raffa, Grazia Daniela, Piazza, Silvano, di Fagagna, Fabrizio d’Adda, Benetti, Roberta, Cortale, Maurizio, Zanconati, Fabrizio, Del Sal, Giannino, Schoeftner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050681/
https://www.ncbi.nlm.nih.gov/pubmed/35484160
http://dx.doi.org/10.1038/s41467-022-29907-z

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