DNA-based copy number analysis confirms genomic evolution of PDX models

Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence away of their tumors of origin. We previously reported the genomic evolution of the copy number (CN) landscapes of PDXs during their engraftment and passaging(1). However, whether PDX models are highly stable...

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Detalles Bibliográficos
Autores principales: Hoge, Anna C. H., Getz, Michal, Zimmer, Anat, Ko, Minjeong, Raz, Linoy, Beroukhim, Rameen, Golub, Todd R., Ha, Gavin, Ben-David, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050710/
https://www.ncbi.nlm.nih.gov/pubmed/35484194
http://dx.doi.org/10.1038/s41698-022-00268-6

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