Dual mTORC1/2 inhibition compromises cell defenses against exogenous stress potentiating Obatoclax-induced cytotoxicity in atypical teratoid/rhabdoid tumors

Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive growth and poor survival. Targeting the mTOR pathway with the dua...

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Detalles Bibliográficos
Autores principales: Parkhurst, Ashlyn, Wang, Sabrina Z., Findlay, Tyler R., Malebranche, Kristen J., Odabas, Arman, Alt, Jesse, Maxwell, Micah J., Kaur, Harpreet, Peer, Cody J., Figg, William D., Warren, Katherine E., Slusher, Barbara S., Eberhart, Charles G., Raabe, Eric H., Rubens, Jeffrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050713/
https://www.ncbi.nlm.nih.gov/pubmed/35484114
http://dx.doi.org/10.1038/s41419-022-04868-9

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