Discovery of lixisenatide analogues as long-acting hypoglycemic agents using novel peptide half-life extension technology based on mycophenolic acid

Noncovalent binding of peptides to human serum albumin protects against renal clearance and enzymatic degradation. Herein, we investigated the effect of mycophenolic acid (MPA) albumin binders for improving the stability of peptides. For proof-of-principle, the short acting glucagon-like peptide-1 (...

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Detalles Bibliográficos
Autores principales: Tang, Chunli, Li, Qing, Deng, Xiaoyan, Wu, Weiwei, Liao, Liufeng, Liang, Kai, Huo, Rongrui, Li, Chenglin, Han, Jing, Tang, Weizhong, Jiang, Neng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050719/
https://www.ncbi.nlm.nih.gov/pubmed/35496622
http://dx.doi.org/10.1039/d0ra01002b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050719/
https://www.ncbi.nlm.nih.gov/pubmed/35496622
http://dx.doi.org/10.1039/d0ra01002b

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