Cargando…
Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine
Glutamate is implicated in migraine pathogenesis including central sensitization and pain transmission. Altered plasma glutamate levels has been noted in migraine. Chronic migraine (CM) presented a higher degree of central sensitization and pain transmission than episodic migraine (EM). However, no...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050726/ https://www.ncbi.nlm.nih.gov/pubmed/35484312 http://dx.doi.org/10.1038/s41598-022-10883-9 |
_version_ | 1784696433721475072 |
---|---|
author | Park, Chae Gyu Chu, Min Kyung |
author_facet | Park, Chae Gyu Chu, Min Kyung |
author_sort | Park, Chae Gyu |
collection | PubMed |
description | Glutamate is implicated in migraine pathogenesis including central sensitization and pain transmission. Altered plasma glutamate levels has been noted in migraine. Chronic migraine (CM) presented a higher degree of central sensitization and pain transmission than episodic migraine (EM). However, no study has evaluated plasma glutamate levels separately in EM and CM. This study aimed to assess plasma glutamate levels in EM and CM compared to controls. An enzyme-linked immunosorbent assay was used to assess plasma glutamate levels in females with EM (n = 98) and CM (n = 92) as well as controls (n = 50). Plasma glutamate levels in participants with EM (median and interquartile range, 49.73 [40.82–66.12] μmol/L, p < 0.001) and CM (58.70 [44.64–72.46] μmol/L, p < 0.001) were significantly higher than those in controls (38.79 [29.50–53.60] μmol/L). Glutamate levels were not significantly different between participants with EM and CM (p = 0.075). There was no significant association of plasma glutamate levels with headache frequency (exponential and 95% confidence interval, 1.285 [0.941–1.755]) and intensity (mild, 59.95 [59.95–59.95] μmol/L vs. moderate, 52.76 [40.83–106.89] μmol/L vs. severe, 55.16 [42.34–68.03] μmol/L, p = 0.472). The plasma glutamate level is a potential indicator for EM and CM. |
format | Online Article Text |
id | pubmed-9050726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90507262022-04-30 Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine Park, Chae Gyu Chu, Min Kyung Sci Rep Article Glutamate is implicated in migraine pathogenesis including central sensitization and pain transmission. Altered plasma glutamate levels has been noted in migraine. Chronic migraine (CM) presented a higher degree of central sensitization and pain transmission than episodic migraine (EM). However, no study has evaluated plasma glutamate levels separately in EM and CM. This study aimed to assess plasma glutamate levels in EM and CM compared to controls. An enzyme-linked immunosorbent assay was used to assess plasma glutamate levels in females with EM (n = 98) and CM (n = 92) as well as controls (n = 50). Plasma glutamate levels in participants with EM (median and interquartile range, 49.73 [40.82–66.12] μmol/L, p < 0.001) and CM (58.70 [44.64–72.46] μmol/L, p < 0.001) were significantly higher than those in controls (38.79 [29.50–53.60] μmol/L). Glutamate levels were not significantly different between participants with EM and CM (p = 0.075). There was no significant association of plasma glutamate levels with headache frequency (exponential and 95% confidence interval, 1.285 [0.941–1.755]) and intensity (mild, 59.95 [59.95–59.95] μmol/L vs. moderate, 52.76 [40.83–106.89] μmol/L vs. severe, 55.16 [42.34–68.03] μmol/L, p = 0.472). The plasma glutamate level is a potential indicator for EM and CM. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9050726/ /pubmed/35484312 http://dx.doi.org/10.1038/s41598-022-10883-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Park, Chae Gyu Chu, Min Kyung Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title | Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title_full | Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title_fullStr | Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title_full_unstemmed | Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title_short | Interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
title_sort | interictal plasma glutamate levels are elevated in individuals with episodic and chronic migraine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050726/ https://www.ncbi.nlm.nih.gov/pubmed/35484312 http://dx.doi.org/10.1038/s41598-022-10883-9 |
work_keys_str_mv | AT parkchaegyu interictalplasmaglutamatelevelsareelevatedinindividualswithepisodicandchronicmigraine AT chuminkyung interictalplasmaglutamatelevelsareelevatedinindividualswithepisodicandchronicmigraine |