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Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017

Endometriosis is a female hormone-dependent disease, possibly related to endocrine disruptor exposure. We aimed to monitor this disease nationwide in France and analyze spatial trends at a fine scale to explore possible environmental contributing risk factors. We conducted a retrospective national d...

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Autores principales: Le Moal, Joëlle, Goria, Sarah, Chesneau, Julie, Fauconnier, Arnaud, Kvaskoff, Marina, De Crouy-Chanel, Perrine, Kahn, Vanessa, Daraï, Emile, Canis, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050825/
https://www.ncbi.nlm.nih.gov/pubmed/35484205
http://dx.doi.org/10.1038/s41598-022-11017-x
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author Le Moal, Joëlle
Goria, Sarah
Chesneau, Julie
Fauconnier, Arnaud
Kvaskoff, Marina
De Crouy-Chanel, Perrine
Kahn, Vanessa
Daraï, Emile
Canis, Michel
author_facet Le Moal, Joëlle
Goria, Sarah
Chesneau, Julie
Fauconnier, Arnaud
Kvaskoff, Marina
De Crouy-Chanel, Perrine
Kahn, Vanessa
Daraï, Emile
Canis, Michel
author_sort Le Moal, Joëlle
collection PubMed
description Endometriosis is a female hormone-dependent disease, possibly related to endocrine disruptor exposure. We aimed to monitor this disease nationwide in France and analyze spatial trends at a fine scale to explore possible environmental contributing risk factors. We conducted a retrospective national descriptive study from 2011 to 2017 in females aged 10 years old and over, using comprehensive hospital discharge data. Cases were identified using ICD-10 N80 codes and were localized at their municipality of residence. We defined incident cases as the first hospital stay of patients, without a stay in at least the previous 5 years. We performed statistical analyses according to age and type of endometriosis, and we modeled the temporal, spatial and spatiotemporal trends. We identified 207,462 incident cases of all-type hospitalized endometriosis (83,112 for non-adenomyosis cases). The crude incidence rate for the study period was 9.85/10,000 person-years (3.95/10,000 for non-adenomyosis cases). From 2011 to 2017, the risk of all-type endometriosis increased by 8.5% (95% CI: 3.9; 13.4) (by 3.6% (95% CI: 0.6; 6.8) for non-adenomyosis cases). The risk was geographically heterogeneous, with 20 high-risk hotspots, showing similar results for non-adenomyosis cases. Shifting practice patterns, improved awareness and healthcare disparities interlinked with environmental risk factors could explain these trends.
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spelling pubmed-90508252022-04-30 Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017 Le Moal, Joëlle Goria, Sarah Chesneau, Julie Fauconnier, Arnaud Kvaskoff, Marina De Crouy-Chanel, Perrine Kahn, Vanessa Daraï, Emile Canis, Michel Sci Rep Article Endometriosis is a female hormone-dependent disease, possibly related to endocrine disruptor exposure. We aimed to monitor this disease nationwide in France and analyze spatial trends at a fine scale to explore possible environmental contributing risk factors. We conducted a retrospective national descriptive study from 2011 to 2017 in females aged 10 years old and over, using comprehensive hospital discharge data. Cases were identified using ICD-10 N80 codes and were localized at their municipality of residence. We defined incident cases as the first hospital stay of patients, without a stay in at least the previous 5 years. We performed statistical analyses according to age and type of endometriosis, and we modeled the temporal, spatial and spatiotemporal trends. We identified 207,462 incident cases of all-type hospitalized endometriosis (83,112 for non-adenomyosis cases). The crude incidence rate for the study period was 9.85/10,000 person-years (3.95/10,000 for non-adenomyosis cases). From 2011 to 2017, the risk of all-type endometriosis increased by 8.5% (95% CI: 3.9; 13.4) (by 3.6% (95% CI: 0.6; 6.8) for non-adenomyosis cases). The risk was geographically heterogeneous, with 20 high-risk hotspots, showing similar results for non-adenomyosis cases. Shifting practice patterns, improved awareness and healthcare disparities interlinked with environmental risk factors could explain these trends. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9050825/ /pubmed/35484205 http://dx.doi.org/10.1038/s41598-022-11017-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Le Moal, Joëlle
Goria, Sarah
Chesneau, Julie
Fauconnier, Arnaud
Kvaskoff, Marina
De Crouy-Chanel, Perrine
Kahn, Vanessa
Daraï, Emile
Canis, Michel
Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title_full Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title_fullStr Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title_full_unstemmed Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title_short Increasing incidence and spatial hotspots of hospitalized endometriosis in France from 2011 to 2017
title_sort increasing incidence and spatial hotspots of hospitalized endometriosis in france from 2011 to 2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050825/
https://www.ncbi.nlm.nih.gov/pubmed/35484205
http://dx.doi.org/10.1038/s41598-022-11017-x
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