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Traveling waves of an FKPP-type model for self-organized growth

We consider a reaction–diffusion system of densities of two types of particles, introduced by Hannezo et al. (Cell 171(1):242–255.e27, 2017). It is a simple model for a growth process: active, branching particles form the growing boundary layer of an otherwise static tissue, represented by inactive...

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Autor principal: Kreten, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050826/
https://www.ncbi.nlm.nih.gov/pubmed/35482091
http://dx.doi.org/10.1007/s00285-022-01753-z
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author Kreten, Florian
author_facet Kreten, Florian
author_sort Kreten, Florian
collection PubMed
description We consider a reaction–diffusion system of densities of two types of particles, introduced by Hannezo et al. (Cell 171(1):242–255.e27, 2017). It is a simple model for a growth process: active, branching particles form the growing boundary layer of an otherwise static tissue, represented by inactive particles. The active particles diffuse, branch and become irreversibly inactive upon collision with a particle of arbitrary type. In absence of active particles, this system is in a steady state, without any a priori restriction on the amount of remaining inactive particles. Thus, while related to the well-studied FKPP-equation, this system features a game-changing continuum of steady state solutions, where each corresponds to a possible outcome of the growth process. However, simulations indicate that this system self-organizes: traveling fronts with fixed shape arise under a wide range of initial data. In the present work, we describe all positive and bounded traveling wave solutions, and obtain necessary and sufficient conditions for their existence. We find a surprisingly simple symmetry in the pairs of steady states which are joined via heteroclinic wave orbits. Our approach is constructive: we first prove the existence of almost constant solutions and then extend our results via a continuity argument along the continuum of limiting points.
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spelling pubmed-90508262022-05-07 Traveling waves of an FKPP-type model for self-organized growth Kreten, Florian J Math Biol Article We consider a reaction–diffusion system of densities of two types of particles, introduced by Hannezo et al. (Cell 171(1):242–255.e27, 2017). It is a simple model for a growth process: active, branching particles form the growing boundary layer of an otherwise static tissue, represented by inactive particles. The active particles diffuse, branch and become irreversibly inactive upon collision with a particle of arbitrary type. In absence of active particles, this system is in a steady state, without any a priori restriction on the amount of remaining inactive particles. Thus, while related to the well-studied FKPP-equation, this system features a game-changing continuum of steady state solutions, where each corresponds to a possible outcome of the growth process. However, simulations indicate that this system self-organizes: traveling fronts with fixed shape arise under a wide range of initial data. In the present work, we describe all positive and bounded traveling wave solutions, and obtain necessary and sufficient conditions for their existence. We find a surprisingly simple symmetry in the pairs of steady states which are joined via heteroclinic wave orbits. Our approach is constructive: we first prove the existence of almost constant solutions and then extend our results via a continuity argument along the continuum of limiting points. Springer Berlin Heidelberg 2022-04-28 2022 /pmc/articles/PMC9050826/ /pubmed/35482091 http://dx.doi.org/10.1007/s00285-022-01753-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Kreten, Florian
Traveling waves of an FKPP-type model for self-organized growth
title Traveling waves of an FKPP-type model for self-organized growth
title_full Traveling waves of an FKPP-type model for self-organized growth
title_fullStr Traveling waves of an FKPP-type model for self-organized growth
title_full_unstemmed Traveling waves of an FKPP-type model for self-organized growth
title_short Traveling waves of an FKPP-type model for self-organized growth
title_sort traveling waves of an fkpp-type model for self-organized growth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9050826/
https://www.ncbi.nlm.nih.gov/pubmed/35482091
http://dx.doi.org/10.1007/s00285-022-01753-z
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