Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these...

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Autores principales: Mazzoccanti, Giulia, Manetto, Simone, Bassan, Michele, Foschini, Alberto, Orlandin, Andrea, Ricci, Antonio, Cabri, Walter, Ismail, Omar H., Catani, Martina, Cavazzini, Alberto, Gasparrini, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051050/
https://www.ncbi.nlm.nih.gov/pubmed/35497586
http://dx.doi.org/10.1039/d0ra01296c
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author Mazzoccanti, Giulia
Manetto, Simone
Bassan, Michele
Foschini, Alberto
Orlandin, Andrea
Ricci, Antonio
Cabri, Walter
Ismail, Omar H.
Catani, Martina
Cavazzini, Alberto
Gasparrini, Francesco
author_facet Mazzoccanti, Giulia
Manetto, Simone
Bassan, Michele
Foschini, Alberto
Orlandin, Andrea
Ricci, Antonio
Cabri, Walter
Ismail, Omar H.
Catani, Martina
Cavazzini, Alberto
Gasparrini, Francesco
author_sort Mazzoccanti, Giulia
collection PubMed
description The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.
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spelling pubmed-90510502022-04-29 Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography Mazzoccanti, Giulia Manetto, Simone Bassan, Michele Foschini, Alberto Orlandin, Andrea Ricci, Antonio Cabri, Walter Ismail, Omar H. Catani, Martina Cavazzini, Alberto Gasparrini, Francesco RSC Adv Chemistry The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market. The Royal Society of Chemistry 2020-03-27 /pmc/articles/PMC9051050/ /pubmed/35497586 http://dx.doi.org/10.1039/d0ra01296c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Mazzoccanti, Giulia
Manetto, Simone
Bassan, Michele
Foschini, Alberto
Orlandin, Andrea
Ricci, Antonio
Cabri, Walter
Ismail, Omar H.
Catani, Martina
Cavazzini, Alberto
Gasparrini, Francesco
Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title_full Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title_fullStr Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title_full_unstemmed Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title_short Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography
title_sort boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-errp) liquid chromatography
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051050/
https://www.ncbi.nlm.nih.gov/pubmed/35497586
http://dx.doi.org/10.1039/d0ra01296c
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