Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs

In acquired immune aplastic anemia (AA), pathogenic cytotoxic Th1 cells are activated and expanded, driving an immune response against the hematopoietic stem and progenitor cells (HSPCs) that provokes cell depletion and causes bone marrow failure. However, additional HSPC defects may contribute to h...

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Detalles Bibliográficos
Autores principales: Tellechea, Maria Florencia, Donaires, Flávia S., de Carvalho, Vinícius S., Santana, Bárbara A., da Silva, Fernanda B., Tristão, Raissa S., Moreira, Lílian F., de Souza, Aline F., Armenteros, Yordanka M., Pereira, Lygia V., Calado, Rodrigo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051057/
https://www.ncbi.nlm.nih.gov/pubmed/35484113
http://dx.doi.org/10.1038/s41419-022-04850-5

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