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Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth
Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H(2) molecules within the tumor is challenging. Magnesium (Mg) and its alloys have been extensively used in the clinic as implantable metals. Here we develop, by decorating platinum on the surface of Mg rods, a M...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051066/ https://www.ncbi.nlm.nih.gov/pubmed/35484138 http://dx.doi.org/10.1038/s41467-022-29938-6 |
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author | Yang, Nailin Gong, Fei Liu, Bo Hao, Yu Chao, Yu Lei, Huali Yang, Xiaoyuan Gong, Yuehan Wang, Xianwen Liu, Zhuang Cheng, Liang |
author_facet | Yang, Nailin Gong, Fei Liu, Bo Hao, Yu Chao, Yu Lei, Huali Yang, Xiaoyuan Gong, Yuehan Wang, Xianwen Liu, Zhuang Cheng, Liang |
author_sort | Yang, Nailin |
collection | PubMed |
description | Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H(2) molecules within the tumor is challenging. Magnesium (Mg) and its alloys have been extensively used in the clinic as implantable metals. Here we develop, by decorating platinum on the surface of Mg rods, a Mg-based galvanic cell (MgG), which allows the continuous generation of H(2) in an aqueous environment due to galvanic-cell-accelerated water etching of Mg. By implanting MgG rods into a tumor, H(2) molecules can be generated within the tumor, which induces mitochondrial dysfunction and intracellular redox homeostasis destruction. Meanwhile, the Mg(OH)(2) residue can neutralize the acidic tumor microenvironment (TME). Such MgG rods with the micro-galvanic cell structure enable hydrogen therapy to inhibit the growth of tumors, including murine tumor models, patient-derived xenografts (PDX), as well as VX(2) tumors in rabbits. Our research suggests that the galvanic cells for hydrogen therapy based on implantable metals may be a safe and effective cancer treatment. |
format | Online Article Text |
id | pubmed-9051066 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90510662022-04-30 Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth Yang, Nailin Gong, Fei Liu, Bo Hao, Yu Chao, Yu Lei, Huali Yang, Xiaoyuan Gong, Yuehan Wang, Xianwen Liu, Zhuang Cheng, Liang Nat Commun Article Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H(2) molecules within the tumor is challenging. Magnesium (Mg) and its alloys have been extensively used in the clinic as implantable metals. Here we develop, by decorating platinum on the surface of Mg rods, a Mg-based galvanic cell (MgG), which allows the continuous generation of H(2) in an aqueous environment due to galvanic-cell-accelerated water etching of Mg. By implanting MgG rods into a tumor, H(2) molecules can be generated within the tumor, which induces mitochondrial dysfunction and intracellular redox homeostasis destruction. Meanwhile, the Mg(OH)(2) residue can neutralize the acidic tumor microenvironment (TME). Such MgG rods with the micro-galvanic cell structure enable hydrogen therapy to inhibit the growth of tumors, including murine tumor models, patient-derived xenografts (PDX), as well as VX(2) tumors in rabbits. Our research suggests that the galvanic cells for hydrogen therapy based on implantable metals may be a safe and effective cancer treatment. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9051066/ /pubmed/35484138 http://dx.doi.org/10.1038/s41467-022-29938-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Nailin Gong, Fei Liu, Bo Hao, Yu Chao, Yu Lei, Huali Yang, Xiaoyuan Gong, Yuehan Wang, Xianwen Liu, Zhuang Cheng, Liang Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title | Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title_full | Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title_fullStr | Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title_full_unstemmed | Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title_short | Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
title_sort | magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051066/ https://www.ncbi.nlm.nih.gov/pubmed/35484138 http://dx.doi.org/10.1038/s41467-022-29938-6 |
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