CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer

Helicobacter pylori (H. pylori) is one of the main causes of gastric cancer. It has been reported that circRNAs play a vital role in the development of multiple types of cancer. However, the role of H. pylori-induced circRNAs in the development of gastric cancer has not been studied. In this study,...

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Autores principales: Guo, Ruiting, Cui, Xixi, Li, Xue, Zang, Wen, Chang, Mingjie, Sun, Zenghui, Liu, Zhifang, Sun, Yundong, Jia, Jihui, Li, Wenjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051101/
https://www.ncbi.nlm.nih.gov/pubmed/35484118
http://dx.doi.org/10.1038/s41419-022-04811-y
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author Guo, Ruiting
Cui, Xixi
Li, Xue
Zang, Wen
Chang, Mingjie
Sun, Zenghui
Liu, Zhifang
Sun, Yundong
Jia, Jihui
Li, Wenjuan
author_facet Guo, Ruiting
Cui, Xixi
Li, Xue
Zang, Wen
Chang, Mingjie
Sun, Zenghui
Liu, Zhifang
Sun, Yundong
Jia, Jihui
Li, Wenjuan
author_sort Guo, Ruiting
collection PubMed
description Helicobacter pylori (H. pylori) is one of the main causes of gastric cancer. It has been reported that circRNAs play a vital role in the development of multiple types of cancer. However, the role of H. pylori-induced circRNAs in the development of gastric cancer has not been studied. In this study, we found that H. pylori could induce the upregulation of circMAN1A2 in AGS and BGC823 cells independent of CagA. The downregulation of circMAN1A2 could inhibit the proliferation, migration and invasion of gastric cancer cells, and circMAN1A2 could promote the progression of gastric cancer induced by H. pylori by sponging miR-1236-3p to regulate MTA2 expression. Furthermore, circMAN1A2 knockdown inhibited xenograft tumour growth in vivo, and the overexpression of circMAN1A2 was associated with the progression of gastric cancer. Hence, Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer.
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spelling pubmed-90511012022-04-30 CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer Guo, Ruiting Cui, Xixi Li, Xue Zang, Wen Chang, Mingjie Sun, Zenghui Liu, Zhifang Sun, Yundong Jia, Jihui Li, Wenjuan Cell Death Dis Article Helicobacter pylori (H. pylori) is one of the main causes of gastric cancer. It has been reported that circRNAs play a vital role in the development of multiple types of cancer. However, the role of H. pylori-induced circRNAs in the development of gastric cancer has not been studied. In this study, we found that H. pylori could induce the upregulation of circMAN1A2 in AGS and BGC823 cells independent of CagA. The downregulation of circMAN1A2 could inhibit the proliferation, migration and invasion of gastric cancer cells, and circMAN1A2 could promote the progression of gastric cancer induced by H. pylori by sponging miR-1236-3p to regulate MTA2 expression. Furthermore, circMAN1A2 knockdown inhibited xenograft tumour growth in vivo, and the overexpression of circMAN1A2 was associated with the progression of gastric cancer. Hence, Helicobacter pylori induced circMAN1A2 expression to promote the carcinogenesis of gastric cancer, and circMAN1A2 might be a new potential diagnostic marker and therapeutic target for gastric cancer. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9051101/ /pubmed/35484118 http://dx.doi.org/10.1038/s41419-022-04811-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Guo, Ruiting
Cui, Xixi
Li, Xue
Zang, Wen
Chang, Mingjie
Sun, Zenghui
Liu, Zhifang
Sun, Yundong
Jia, Jihui
Li, Wenjuan
CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title_full CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title_fullStr CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title_full_unstemmed CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title_short CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer
title_sort circman1a2 is upregulated by helicobacter pylori and promotes development of gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051101/
https://www.ncbi.nlm.nih.gov/pubmed/35484118
http://dx.doi.org/10.1038/s41419-022-04811-y
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