A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia

This national administrative investigation of Republic of Korea compared the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders(ASD) in preschool amblyopic children and identified factors that possibly mediate this association. After propensity score (PS) matching,...

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Autores principales: Kim, Myungjin, Lee, Seungwon, Lee, Jung Eun, Kim, Ju Hee, Ha, Eun Kyo, Han, Manyong, Lew, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051132/
https://www.ncbi.nlm.nih.gov/pubmed/35484195
http://dx.doi.org/10.1038/s41598-022-10845-1
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author Kim, Myungjin
Lee, Seungwon
Lee, Jung Eun
Kim, Ju Hee
Ha, Eun Kyo
Han, Manyong
Lew, Helen
author_facet Kim, Myungjin
Lee, Seungwon
Lee, Jung Eun
Kim, Ju Hee
Ha, Eun Kyo
Han, Manyong
Lew, Helen
author_sort Kim, Myungjin
collection PubMed
description This national administrative investigation of Republic of Korea compared the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders(ASD) in preschool amblyopic children and identified factors that possibly mediate this association. After propensity score (PS) matching, 7762 amblyopic children and 31,030 non-amblyopic children were included. Amblyopia was associated with ADHD (aOR:1.687; 95% CI 1.444, 1.970) but not with ASD (aOR: 0.591; 95% CI 0.341, 1.026). Fine motor skill impairment was a mediating factor in association of amblyopia with ADHD, accounting for 4.2% (95% CI 1.7, 8.0). In conclusion, amblyopic children have a greater risk of ADHD, and deficits in fine motor skills mediate this association. We suggest increased attention given to fine motor skill underdevelopment in amblyopic children to prevent the development of ADHD.
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spelling pubmed-90511322022-04-30 A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia Kim, Myungjin Lee, Seungwon Lee, Jung Eun Kim, Ju Hee Ha, Eun Kyo Han, Manyong Lew, Helen Sci Rep Article This national administrative investigation of Republic of Korea compared the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders(ASD) in preschool amblyopic children and identified factors that possibly mediate this association. After propensity score (PS) matching, 7762 amblyopic children and 31,030 non-amblyopic children were included. Amblyopia was associated with ADHD (aOR:1.687; 95% CI 1.444, 1.970) but not with ASD (aOR: 0.591; 95% CI 0.341, 1.026). Fine motor skill impairment was a mediating factor in association of amblyopia with ADHD, accounting for 4.2% (95% CI 1.7, 8.0). In conclusion, amblyopic children have a greater risk of ADHD, and deficits in fine motor skills mediate this association. We suggest increased attention given to fine motor skill underdevelopment in amblyopic children to prevent the development of ADHD. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9051132/ /pubmed/35484195 http://dx.doi.org/10.1038/s41598-022-10845-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Myungjin
Lee, Seungwon
Lee, Jung Eun
Kim, Ju Hee
Ha, Eun Kyo
Han, Manyong
Lew, Helen
A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title_full A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title_fullStr A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title_full_unstemmed A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title_short A nationwide cohort study on the risk of ADHD in children with amblyopia mediated by fine motor skill impairment in East Asia
title_sort nationwide cohort study on the risk of adhd in children with amblyopia mediated by fine motor skill impairment in east asia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051132/
https://www.ncbi.nlm.nih.gov/pubmed/35484195
http://dx.doi.org/10.1038/s41598-022-10845-1
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