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The role of neurotrophin genes involved in the vulnerability to gambling disorder
Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link be...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051155/ https://www.ncbi.nlm.nih.gov/pubmed/35484167 http://dx.doi.org/10.1038/s41598-022-10391-w |
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author | Solé-Morata, Neus Baenas, Isabel Etxandi, Mikel Granero, Roser Forcales, Sonia V. Gené, Manel Barrot, Carme Gómez-Peña, Mónica Menchón, José M. Ramoz, Nicolás Gorwood, Philip Fernández-Aranda, Fernando Jiménez-Murcia, Susana |
author_facet | Solé-Morata, Neus Baenas, Isabel Etxandi, Mikel Granero, Roser Forcales, Sonia V. Gené, Manel Barrot, Carme Gómez-Peña, Mónica Menchón, José M. Ramoz, Nicolás Gorwood, Philip Fernández-Aranda, Fernando Jiménez-Murcia, Susana |
author_sort | Solé-Morata, Neus |
collection | PubMed |
description | Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link between NTF and addiction-related disorders. Thus, we aimed to explore the role of NTF genes and GD with the hypothesis that some NTF gene polymorphisms could constitute biological risk factors. The sample included 166 patients with GD and 191 healthy controls. 36 single nucleotide polymorphisms (SNPs) from NTFs (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium (LD) and haplotype constructions were analyzed, in relationship with the presence of GD. Finally, regulatory elements overlapping the identified SNPs variants associated with GD were searched. The between groups comparisons of allele frequencies indicated that 6 SNPs were potentially associated with GD. Single and multiple-marker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD. The present study supports the involvement of the NTF family in the aetiopathogenesis of GD. An altered cross-regulation of different NTF members signalling pathways might be considered as a biological vulnerability factor for GD. |
format | Online Article Text |
id | pubmed-9051155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90511552022-04-30 The role of neurotrophin genes involved in the vulnerability to gambling disorder Solé-Morata, Neus Baenas, Isabel Etxandi, Mikel Granero, Roser Forcales, Sonia V. Gené, Manel Barrot, Carme Gómez-Peña, Mónica Menchón, José M. Ramoz, Nicolás Gorwood, Philip Fernández-Aranda, Fernando Jiménez-Murcia, Susana Sci Rep Article Evidence about the involvement of genetic factors in the development of gambling disorder (GD) has been assessed. Among studies assessing heritability and biological vulnerability for GD, neurotrophin (NTF) genes have emerged as promising targets, since a growing literature showed a possible link between NTF and addiction-related disorders. Thus, we aimed to explore the role of NTF genes and GD with the hypothesis that some NTF gene polymorphisms could constitute biological risk factors. The sample included 166 patients with GD and 191 healthy controls. 36 single nucleotide polymorphisms (SNPs) from NTFs (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium (LD) and haplotype constructions were analyzed, in relationship with the presence of GD. Finally, regulatory elements overlapping the identified SNPs variants associated with GD were searched. The between groups comparisons of allele frequencies indicated that 6 SNPs were potentially associated with GD. Single and multiple-marker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD. The present study supports the involvement of the NTF family in the aetiopathogenesis of GD. An altered cross-regulation of different NTF members signalling pathways might be considered as a biological vulnerability factor for GD. Nature Publishing Group UK 2022-04-28 /pmc/articles/PMC9051155/ /pubmed/35484167 http://dx.doi.org/10.1038/s41598-022-10391-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Solé-Morata, Neus Baenas, Isabel Etxandi, Mikel Granero, Roser Forcales, Sonia V. Gené, Manel Barrot, Carme Gómez-Peña, Mónica Menchón, José M. Ramoz, Nicolás Gorwood, Philip Fernández-Aranda, Fernando Jiménez-Murcia, Susana The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title | The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title_full | The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title_fullStr | The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title_full_unstemmed | The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title_short | The role of neurotrophin genes involved in the vulnerability to gambling disorder |
title_sort | role of neurotrophin genes involved in the vulnerability to gambling disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051155/ https://www.ncbi.nlm.nih.gov/pubmed/35484167 http://dx.doi.org/10.1038/s41598-022-10391-w |
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