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An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES

BACKGROUND: Migraine is a common neurological disease and an important cause of disability worldwide. Serum urate is the end product of purine metabolism in Homo sapiens and other hominoids. Previous studies about the serum urate level in migraine were contradictory. Hence, we present a cross-sectio...

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Autores principales: Hong, Peiwei, Liu, Yao, Wan, Yang, Xiong, Hai, Xu, Yanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051317/
https://www.ncbi.nlm.nih.gov/pubmed/35493816
http://dx.doi.org/10.3389/fneur.2022.871783
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author Hong, Peiwei
Liu, Yao
Wan, Yang
Xiong, Hai
Xu, Yanming
author_facet Hong, Peiwei
Liu, Yao
Wan, Yang
Xiong, Hai
Xu, Yanming
author_sort Hong, Peiwei
collection PubMed
description BACKGROUND: Migraine is a common neurological disease and an important cause of disability worldwide. Serum urate is the end product of purine metabolism in Homo sapiens and other hominoids. Previous studies about the serum urate level in migraine were contradictory. Hence, we present a cross-section study to clarify the association between serum urate and migraine and explore the dose effect of serum urate on migraine. MATERIALS AND METHODS: The data for this cross-section study were acquired from the National Health and Nutrition Examination Survey (NHANES). A diagnosis of migraine was made through patient the self-reported and prescription medication. For data analysis, the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piecewise linear regression model were utilized for data analysis. All data analysis was conducted on Empower software. RESULTS: Totally, 18,637 participants were enrolled in this study, of which 208 were migraineurs. The rest were set as control. There existed a statistically significant difference in mean age (p = 0.0389), gender (p< 0.0001), race (p< 0.0001), data release cycle (p = 0.048), drug usage, blood albumin (p< 0.0001), blood total protein (p< 0.0001), hemoglobin (p< 0.0001), serum iron (p< 0.0001), and serum urate (p< 0.0001) between the two groups. According to logistic regression models, there existed no consistent linear relationship between serum urate and migraine before (model 1: odd ratio (OR) = 0.83, p = 0.0004) or after adjusting for confounders (model 2: OR = 0.96, p = 0.5198; model 3: OR = 0.84, p = 0.0184). However, smooth curve fittings found an exponential curve relationship between serum urate and migraine. Furthermore, when serum urate was more than 7.8 mg/dl, higher serum urate was correlated with higher migraine occurrence (model 1: OR = 1.54, p = 0.0022; model 2: OR = 1.51, p = 0.0050; model 3: OR = 1.77, p = 0.0348). Besides, 8 out of the 208 migraineurs had a serum urate higher than 7.8 mg/dl. CONCLUSIONS: In conclusion, there existed an exponential curve relationship between serum urate and migraine, with an infliction point of 7.8 mg/dl. When serum urate was more than 7.8 mg/dl, increased serum urate was correlated with higher migraine occurrence.
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spelling pubmed-90513172022-04-30 An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES Hong, Peiwei Liu, Yao Wan, Yang Xiong, Hai Xu, Yanming Front Neurol Neurology BACKGROUND: Migraine is a common neurological disease and an important cause of disability worldwide. Serum urate is the end product of purine metabolism in Homo sapiens and other hominoids. Previous studies about the serum urate level in migraine were contradictory. Hence, we present a cross-section study to clarify the association between serum urate and migraine and explore the dose effect of serum urate on migraine. MATERIALS AND METHODS: The data for this cross-section study were acquired from the National Health and Nutrition Examination Survey (NHANES). A diagnosis of migraine was made through patient the self-reported and prescription medication. For data analysis, the weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piecewise linear regression model were utilized for data analysis. All data analysis was conducted on Empower software. RESULTS: Totally, 18,637 participants were enrolled in this study, of which 208 were migraineurs. The rest were set as control. There existed a statistically significant difference in mean age (p = 0.0389), gender (p< 0.0001), race (p< 0.0001), data release cycle (p = 0.048), drug usage, blood albumin (p< 0.0001), blood total protein (p< 0.0001), hemoglobin (p< 0.0001), serum iron (p< 0.0001), and serum urate (p< 0.0001) between the two groups. According to logistic regression models, there existed no consistent linear relationship between serum urate and migraine before (model 1: odd ratio (OR) = 0.83, p = 0.0004) or after adjusting for confounders (model 2: OR = 0.96, p = 0.5198; model 3: OR = 0.84, p = 0.0184). However, smooth curve fittings found an exponential curve relationship between serum urate and migraine. Furthermore, when serum urate was more than 7.8 mg/dl, higher serum urate was correlated with higher migraine occurrence (model 1: OR = 1.54, p = 0.0022; model 2: OR = 1.51, p = 0.0050; model 3: OR = 1.77, p = 0.0348). Besides, 8 out of the 208 migraineurs had a serum urate higher than 7.8 mg/dl. CONCLUSIONS: In conclusion, there existed an exponential curve relationship between serum urate and migraine, with an infliction point of 7.8 mg/dl. When serum urate was more than 7.8 mg/dl, increased serum urate was correlated with higher migraine occurrence. Frontiers Media S.A. 2022-04-15 /pmc/articles/PMC9051317/ /pubmed/35493816 http://dx.doi.org/10.3389/fneur.2022.871783 Text en Copyright © 2022 Hong, Liu, Wan, Xiong and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hong, Peiwei
Liu, Yao
Wan, Yang
Xiong, Hai
Xu, Yanming
An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title_full An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title_fullStr An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title_full_unstemmed An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title_short An Exponential Curve Relationship Between Serum Urate and Migraine: A Cross-Section Study From NHANES
title_sort exponential curve relationship between serum urate and migraine: a cross-section study from nhanes
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051317/
https://www.ncbi.nlm.nih.gov/pubmed/35493816
http://dx.doi.org/10.3389/fneur.2022.871783
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