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Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control

OBJECTIVE: Treatment delays in prostate cancer have been characterised, although not explicitly in men undergoing transperineal prostate biopsies. We aimed to determine if delays to radical prostatectomy correlate with adverse outcomes using a contemporary population-based cohort of men diagnosed by...

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Autores principales: Qu, Liang G., Jack, Gregory, Perera, Marlon, Evans, Melanie, Evans, Sue, Bolton, Damien, Papa, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Second Military Medical University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051344/
https://www.ncbi.nlm.nih.gov/pubmed/35509478
http://dx.doi.org/10.1016/j.ajur.2021.08.008
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author Qu, Liang G.
Jack, Gregory
Perera, Marlon
Evans, Melanie
Evans, Sue
Bolton, Damien
Papa, Nathan
author_facet Qu, Liang G.
Jack, Gregory
Perera, Marlon
Evans, Melanie
Evans, Sue
Bolton, Damien
Papa, Nathan
author_sort Qu, Liang G.
collection PubMed
description OBJECTIVE: Treatment delays in prostate cancer have been characterised, although not explicitly in men undergoing transperineal prostate biopsies. We aimed to determine if delays to radical prostatectomy correlate with adverse outcomes using a contemporary population-based cohort of men diagnosed by transperineal biopsies. METHODS: This study analysed men with prostate cancer of the International Society for Urological Pathology grade group ≥2, diagnosed by transperineal prostate biopsies who underwent prostatectomy, using the prospectively data from 1 January 2014 to 30 June 2018 Prostate Cancer Outcomes Registry-Victoria. Data were analysed according to stratified demographic and disease characteristics. Time intervals from biopsy (28, 60, 90, 120, and 270 days) were compared using odds ratios and regression analyses for proportion of upgrading, early biochemical recurrence, pT3 disease at prostatectomy, and positive surgical margins. RESULTS: In total, 2008 men were analysed. There were 306 (16.7%) men with upgrading, 151 (8.4%) with biochemical recurrence, 1068 (54.1%) with pT3 disease, and 464 (23.1%) with positive surgical margins (percentages excluded patients with missing data). All adverse outcomes studied were significantly associated with higher prostate-specific antigen and grade at diagnosis. Delays of 120–270 days did not adversely alter the incidence of Gleason upgrading, pT3, or recurrence. Delays (most frequent 60–89 days, 28%) were associated with positive surgical margins but not monotonically. Regression modelling demonstrated no increased likelihood of most adverse outcomes for up to 270 days. CONCLUSION: Men with prostate cancer of grade group ≥2 diagnosed through transperineal biopsy may wait up to 270 days for a prostatectomy without a greater likelihood of upgrading, pT3 disease, positive surgical margins, or biochemical recurrence.
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spelling pubmed-90513442022-05-03 Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control Qu, Liang G. Jack, Gregory Perera, Marlon Evans, Melanie Evans, Sue Bolton, Damien Papa, Nathan Asian J Urol Original Article OBJECTIVE: Treatment delays in prostate cancer have been characterised, although not explicitly in men undergoing transperineal prostate biopsies. We aimed to determine if delays to radical prostatectomy correlate with adverse outcomes using a contemporary population-based cohort of men diagnosed by transperineal biopsies. METHODS: This study analysed men with prostate cancer of the International Society for Urological Pathology grade group ≥2, diagnosed by transperineal prostate biopsies who underwent prostatectomy, using the prospectively data from 1 January 2014 to 30 June 2018 Prostate Cancer Outcomes Registry-Victoria. Data were analysed according to stratified demographic and disease characteristics. Time intervals from biopsy (28, 60, 90, 120, and 270 days) were compared using odds ratios and regression analyses for proportion of upgrading, early biochemical recurrence, pT3 disease at prostatectomy, and positive surgical margins. RESULTS: In total, 2008 men were analysed. There were 306 (16.7%) men with upgrading, 151 (8.4%) with biochemical recurrence, 1068 (54.1%) with pT3 disease, and 464 (23.1%) with positive surgical margins (percentages excluded patients with missing data). All adverse outcomes studied were significantly associated with higher prostate-specific antigen and grade at diagnosis. Delays of 120–270 days did not adversely alter the incidence of Gleason upgrading, pT3, or recurrence. Delays (most frequent 60–89 days, 28%) were associated with positive surgical margins but not monotonically. Regression modelling demonstrated no increased likelihood of most adverse outcomes for up to 270 days. CONCLUSION: Men with prostate cancer of grade group ≥2 diagnosed through transperineal biopsy may wait up to 270 days for a prostatectomy without a greater likelihood of upgrading, pT3 disease, positive surgical margins, or biochemical recurrence. Second Military Medical University 2022-04 2021-09-06 /pmc/articles/PMC9051344/ /pubmed/35509478 http://dx.doi.org/10.1016/j.ajur.2021.08.008 Text en © 2022 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Qu, Liang G.
Jack, Gregory
Perera, Marlon
Evans, Melanie
Evans, Sue
Bolton, Damien
Papa, Nathan
Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title_full Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title_fullStr Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title_full_unstemmed Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title_short Impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
title_sort impact of delay from transperineal biopsy to radical prostatectomy upon objective measures of cancer control
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051344/
https://www.ncbi.nlm.nih.gov/pubmed/35509478
http://dx.doi.org/10.1016/j.ajur.2021.08.008
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