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Surgical Management of Small Bowel Crohn's Disease
Crohn's disease in the small bowel could present itself as an inflammatory stricture, a fibrotic stricture as penetrating disease or a combination of both. It is pertinent to differentiate the disease process as well as its extent to effectively manage the disease. Currently, a combination of m...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051431/ https://www.ncbi.nlm.nih.gov/pubmed/35495760 http://dx.doi.org/10.3389/fsurg.2022.759668 |
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author | Chandrasinghe, Pramodh |
author_facet | Chandrasinghe, Pramodh |
author_sort | Chandrasinghe, Pramodh |
collection | PubMed |
description | Crohn's disease in the small bowel could present itself as an inflammatory stricture, a fibrotic stricture as penetrating disease or a combination of both. It is pertinent to differentiate the disease process as well as its extent to effectively manage the disease. Currently, a combination of medical and surgical therapies forms part of the treatment plan while the debate of which therapy is better continues. In managing the strictures, identification of the disease process through imaging plays a pivotal role as inflammatory strictures respond to anti-tumor necrosis factor (TNF) and biological agents, while fibrotic strictures require endoscopic or surgical intervention. Recent evidence suggests a larger role for surgical excision, particularly in ileocolic disease, while achieving a balance between disease clearance and bowel preservation. Several adaptations to the surgical technique, such as wide mesenteric excision, side to side or Kono-S anastomosis, and long-term metronidazole therapy, are being undertaken even though their absolute benefit is yet to be determined. Penetrating disease requires a broader multidisciplinary approach with a particular focus on nutrition, skincare, and intestinal failure management. The current guidance directs toward early surgical intervention for penetrating disease when feasible. Accurate preoperative imaging, medical management of active diseases, and surgical decision-making based on experience and evidence play a key role in success. |
format | Online Article Text |
id | pubmed-9051431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90514312022-04-30 Surgical Management of Small Bowel Crohn's Disease Chandrasinghe, Pramodh Front Surg Surgery Crohn's disease in the small bowel could present itself as an inflammatory stricture, a fibrotic stricture as penetrating disease or a combination of both. It is pertinent to differentiate the disease process as well as its extent to effectively manage the disease. Currently, a combination of medical and surgical therapies forms part of the treatment plan while the debate of which therapy is better continues. In managing the strictures, identification of the disease process through imaging plays a pivotal role as inflammatory strictures respond to anti-tumor necrosis factor (TNF) and biological agents, while fibrotic strictures require endoscopic or surgical intervention. Recent evidence suggests a larger role for surgical excision, particularly in ileocolic disease, while achieving a balance between disease clearance and bowel preservation. Several adaptations to the surgical technique, such as wide mesenteric excision, side to side or Kono-S anastomosis, and long-term metronidazole therapy, are being undertaken even though their absolute benefit is yet to be determined. Penetrating disease requires a broader multidisciplinary approach with a particular focus on nutrition, skincare, and intestinal failure management. The current guidance directs toward early surgical intervention for penetrating disease when feasible. Accurate preoperative imaging, medical management of active diseases, and surgical decision-making based on experience and evidence play a key role in success. Frontiers Media S.A. 2022-04-15 /pmc/articles/PMC9051431/ /pubmed/35495760 http://dx.doi.org/10.3389/fsurg.2022.759668 Text en Copyright © 2022 Chandrasinghe. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Chandrasinghe, Pramodh Surgical Management of Small Bowel Crohn's Disease |
title | Surgical Management of Small Bowel Crohn's Disease |
title_full | Surgical Management of Small Bowel Crohn's Disease |
title_fullStr | Surgical Management of Small Bowel Crohn's Disease |
title_full_unstemmed | Surgical Management of Small Bowel Crohn's Disease |
title_short | Surgical Management of Small Bowel Crohn's Disease |
title_sort | surgical management of small bowel crohn's disease |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9051431/ https://www.ncbi.nlm.nih.gov/pubmed/35495760 http://dx.doi.org/10.3389/fsurg.2022.759668 |
work_keys_str_mv | AT chandrasinghepramodh surgicalmanagementofsmallbowelcrohnsdisease |